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Título

Cytoneme-mediated cell-cell contacts for hedgehog reception

AutorGonzález-Méndez, Laura ; Seijo-Barandiarán, Irene; Guerrero, Isabel
Fecha de publicación21-ago-2017
EditoreLife Sciences Publications
CitacióneLife 6 (2017)
ResumenMorphogens regulate tissue patterning through their distribution in concentration gradients. Emerging research establishes a role for specialized signalling filopodia, or cytonemes, in morphogen dispersion and signalling. Previously we demonstrated that Hedgehog (Hh) morphogen is transported via vesicles along cytonemes emanating from signal-producing cells to form a gradient in Drosophila epithelia. However, the mechanisms for signal reception and transfer are still undefined. Here, we demonstrate that cytonemes protrusding from Hh-receiving cells contribute to Hh gradient formation. The canonical Hh receptor Patched is localized in these cellular protrusions and Hh reception takes place in membrane contact sites between Hh-sending and Hh-receiving cytonemes. These two sets of cytonemes have similar dynamics and both fall in two different dynamic behaviours. Furthermore, both the Hh co-receptor Interference hedgehog (Ihog) and the glypicans are critical for this cell-cell cytoneme mediated interaction. These findings suggest that the described contact sites might facilitate morphogen presentation and reception.
URIhttp://hdl.handle.net/10261/165470
Identificadoresdoi: 10.7554/eLife.24045
issn: 2050-084X
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