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Tuning of glyconanomaterial shape and size for selective bacterial cell agglutination

AuthorsCid Martín, J. J.; Assali, Mohyeddin ; Fernández García, Elisabet ; Valdivia, Victoria ; Sánchez-Fernández, Elena M. ; García Fernández, José Manuel ; Wellinger, Ralf Erik ; Fernández, I.; Khiar el Wahabi, Noureddine
Issue Date2016
PublisherRoyal Society of Chemistry (Great Britain)
CitationJournal of Materials Chemistry B 4(11): 2028-2037 (2016)
AbstractMultivalent glycosystems are potential candidates for anti-adhesive therapy, a non-lethal approach against the ever increasing antibiotic resistance of pathogenic bacteria. In order to fine-tune the glyconanomaterial size and shape for selective bacterial cell agglutination, herein we report the synthesis of sugar-coated dynamic and polymeric 3D-micelles and 1D-carbon nanotubes. The reported shot-gun like synthetic approach is based on the ability of diacetylenic-based neoglycolipids to self-assemble into micelles in water and hierarchically self-assemble into hemimicelles on a single-walled carbon nanotube surface. The affinity of the nanosystems was preliminarily assessed by enzyme-linked lectin assay (ELLA) using the mannose-specific Concanavalin A lectin as a model receptor. Relative binding potency enhancements, compared to methyl ¿-d-mannopyranoside used as control, from 10- to 25- to 2340-folds in sugar molar basis were observed when passing from 3D dynamic micelles to static micelles, to 1D-mannose coated carbon nanotubes, respectively, indicative of a significant cluster glycoside effect. Importantly, these results were confirmed in vivo showing that the 1D-glyconanoring-coated carbon nanotubes efficiently and selectively regulate the agglutination and proliferation of the enterobacteria Escherichia coli type 1 fimbriae. These findings highlight the potential of sugar coated nano-materials as novel and effective tools in the control of bacterial pathogenesis.
Identifiersdoi: 10.1039/C5TB02488A
issn: 2050-750X
e-issn: 2050-7518
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