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Title

Cognitive decline in neuronal aging and Alzheimer's disease: Role of NMDA receptors and associated proteins

AuthorsÁvila, Jesús CSIC ORCID; Llorens-Martín, M. CSIC ORCID; Pallas-Bazarra, Noemí CSIC ORCID; Bolós, Marta; Perea, Juan Ramón; Rodríguez-Matellán, Alberto G.; Hernández, Félix
KeywordsTau proteins
Dendritic spines
Therapies
Cognition
Neurotransmitter agents
Issue Date10-Nov-2017
CitationFrontiers in Neuroscience 11 (2017)
AbstractMolecular changes associated with neuronal aging lead to a decrease in cognitive capacity. Here we discuss these alterations at the level of brain regions, brain cells, and brain membrane and cytoskeletal proteins with an special focus in NMDA molecular changes through aging and its effect in cognitive decline and Alzheimer disease. Here, we propose that some neurodegenerative disorders, like Alzheimer's disease (AD), are characterized by an increase and acceleration of some of these changes.
URIhttp://hdl.handle.net/10261/165322
DOIhttp://dx.doi.org/10.3389/fnins.2017.00626
Identifiersdoi: 10.3389/fnins.2017.00626
issn: 1662-453X
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