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Extracardiac septum transversum/proepicardial endothelial cells pattern embryonic coronary arterio-venous connections

AutorCano, Elena; Carmona, Rita; Rojas, Anabel ; Muñoz-Chápuli, Ramón; Pérez-Pomares, José M.
Palabras claveGata4
Proepicardium
Septum transversum
Coronary endothelium
Wt1
Fecha de publicación2016
EditorNational Academy of Sciences (U.S.)
CitaciónProceedings of the National Academy of Sciences 113(3): 656-661 (2016)
ResumenRecent reports suggest that mammalian embryonic coronary endothelium (CoE) originates from the sinus venosus and ventricular endocardium. However, the contribution of extracardiac cells to CoE is thought to be minor and nonsignificant for coronary formation. Using classic (Wt1) and previously undescribed (G2-Gata4) transgenic mouse models for the study of coronary vascular development, we show that extracardiac septum transversum/proepicardium (ST/PE)-derived endothelial cells are required for the formation of ventricular coronary arterio-venous vascular connections. Our results indicate that at least 20% of embryonic coronary arterial and capillary endothelial cells derive from the ST/PE compartment. Moreover, we show that conditional deletion of the ST/PE lineage-specific Wilms' tumor suppressor gene (Wt1) in the ST/PE ofG2-Gata4 mice and in the endothelium of Tie2 mice disrupts embryonic coronary transmural patterning, leading to embryonic death. Taken together, our results demonstrate that ST/PE-derived endothelial cells contribute significantly to and are required for proper coronary vascular morphogenesis.
DescripciónCano, Elena et al.
URIhttp://hdl.handle.net/10261/165202
Identificadoresdoi: 10.1073/pnas.1509834113
e-issn: 1091-6490
issn: 0027-8424
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