English   español  
Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/165174
COMPARTIR / IMPACTO:
Estadísticas
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:
Título

Lysosome-dependent cell death and deregulated autophagy induced by amine-modified polystyrene nanoparticles

AutorWang, Fengjuan; Salvati, Anna; Boya, Patricia
Palabras claveAutophagy
Cationic nanoparticles
Lysosomal membrane permeabilization
Nanotoxicity
Reactive oxygen species
Fecha de publicación11-abr-2018
EditorRoyal Society of Chemistry (Great Britain)
CitaciónOpen Biol 8(4) 170271 (2018)
ResumenNanoparticles (NPs) typically accumulate in lysosomes. However, their impact on lysosomal function, as well as autophagy, a lysosomal degradative pathway, is still not well known. We have previously reported in the 1321N1 cell line that amine-modified polystyrene (NH2-PS) NPs induce apoptosis through damage initiated in the lysosomes leading ultimately to release of lysosomal content in the cytosol, followed by apoptosis. Here, by using a combination of biochemical and cell biological approaches, we have characterized in a mouse embryonic fibroblast cell line that the lysosomal alterations induced by NH2-PS NPs is progressive, initiating from mild lysosomal membrane permeabilization (LMP), to expansion of lysosomal volume and intensive LMP before the summit of cell death. Though the cells initially seem to induce autophagy as a surviving mechanism, the damage of NH2-PS NPs to lysosomes probably results in lysosomal dysfunctions, leading to blockage of autophagic flux at the level of lysosomes and the eventual cell death.
Descripción13 p.-5 fig.
Versión del editorhttp://dx.doi.org/10.1098/rsob.170271
URIhttp://hdl.handle.net/10261/165174
DOI10.1098/rsob.170271
E-ISSN2046-2441
Aparece en las colecciones: (CIB) Artículos
Ficheros en este ítem:
Fichero Descripción Tamaño Formato  
Open Biology 2018.pdfArtículo principal1,78 MBAdobe PDFVista previa
Visualizar/Abrir
Mostrar el registro completo
 

Artículos relacionados:


NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.