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Título

Chromatin structure and pre-mRNA processing work together

AutorJimeno-González, Silvia ; Reyes, José C.
Palabras claveNucleosome
Transcription termination
Splicing
Promoter proximal pausing
mRNA capping
Fecha de publicación2016
EditorTaylor & Francis
CitaciónTranscription 7(3): 63-68 (2016)
ResumenChromatin is the natural context for transcription elongation. However, the elongating RNA polymerase II (RNAPII) is forced to pause by the positioned nucleosomes present in gene bodies. Here, we briefly discuss the current results suggesting that those pauses could serve as a mechanism to coordinate transcription elongation with pre-mRNA processing. Further, histone post-translational modifications have been found to regulate the recruitment of factors involved in pre-mRNA processing. This view highlights the important regulatory role of the chromatin context in the whole process of the mature mRNA synthesis.
URIhttp://hdl.handle.net/10261/165159
Identificadoresdoi: 10.1080/21541264.2016.1168507
e-issn: 2154-1272
issn: 2154-1264
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