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Título

Adenohypophysis placodal precursors exhibit distinctive features within the rostral preplacodal ectoderm

AutorSánchez-Arrones, Luisa ; Sandonís Consuegra, África; Cardozo, Marcos ; Bovolenta, Paola
Palabras claveRNA-seq
Chick
Pituitary
Midline
Cell movement
Adhesion
Sp8
Fecha de publicación2017
EditorCompany of Biologists
CitaciónDevelopment 144: 3521- 3532 (2017)
ResumenPlacodes are discrete thickenings of the vertebrate cranial ectoderm that generate morpho-functionally distinct structures, such as the adenohypophysis, olfactory epithelium and lens. All placodes arise from a horseshoe-shaped preplacodal ectoderm in which the precursors of individual placodes are intermingled. However, fatemap studies indicated that cells positioned at the preplacodal midline give rise to only the adenohypophyseal placode, suggesting a unique organization of these precursors within the preplacode. To test this possibility, we combined embryological and molecular approaches in chick embryos to show that, at gastrula stage, adenohypophyseal precursors are clustered in the median preplacodal ectoderm, largely segregated from those of the adjacent olfactory placode. Median precursors are elongated, densely packed and, at neurula stage, express a molecular signature that distinguishes them from the remaining preplacodal cells. Olfactory placode precursors and midline neural cells can replace ablated adenohypophyseal precursors up to head-fold stage, although with a more plastic organization. We thus propose that adenohypophyseal placode precursors are unique within the preplacodal ectoderm possibly because they originate the only single placode and the only one with an endocrine character.
URIhttp://hdl.handle.net/10261/164974
Identificadoresdoi: 10.1242/dev.149724
issn: 1477-9129
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