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dc.contributor.author | García-Rodríguez, Sonia | - |
dc.contributor.author | Rosal-Vela, Antonio | - |
dc.contributor.author | Zumaquero, Esther | - |
dc.contributor.author | Corbí, Angel L. | - |
dc.contributor.author | Merino, Ramón | - |
dc.contributor.author | Zubiaur, Mercedes | - |
dc.contributor.author | Sancho, Jaime | - |
dc.date.accessioned | 2018-05-17T07:57:07Z | - |
dc.date.available | 2018-05-17T07:57:07Z | - |
dc.date.issued | 2017 | - |
dc.identifier.citation | 4th Madrid Meeting on Dendritic Cells and Macrophages (2017) | - |
dc.identifier.uri | http://hdl.handle.net/10261/164851 | - |
dc.description | Resumen del póster presentado al 4th Madrid Meeting on Dendritic ells and Macrophages, celebrado del 27 al 28 de marzo de 2017 en el Centro Nacional de Biotecnología (CNB-CSIC).-- García-Rodríguez, Sonia et al. | - |
dc.description.abstract | This study was undertaken to investigate the role of CD38 in a murine model of lupus. Cd38-/- and Cd38-/-/Art2-/- mice, but not Art2-/- mice, developed less severe lupus compared to pristane-treated WT controls, characterized by decreased expression of IFN-I-stimulated genes (ISGs), defective number of peritoneal CCR2hi Ly6Chi inflammatory monocytes, TNF-¿-producing neutrophils, decreased production of anti-single-stranded DNA, anti-nRNP autoantibodies, and ameliorated glomerulonephritis. Using multivariate analyses, increased expression of ISGs plus Tlr7 and Tlr9 genes in pristane-treated peritoneal exudate cells (PECs) discriminated pristane-treated mice from non-treated mice, and within pristane-treated mice those with a milder inflammatory response (Cd38-/- and Cd38-/-/Art2-/-) from those with stronger response (WT and Art2-/-). Similar clustering analyses performed at the onset of the lupus disease indicated that the differences in gene expression between pristane-treated WT and Cd38-/- mice shifted from PECs and BM cells to secondary lymphoid tissues as the spleen. A defective pristane-induced apoptotic-mediated cell death was observed in peritoneal Cd38-/- Ly6Chi monocytes, which may reduce the source of endogenous TLR7 ligands, the driven force for inflammatory cytokine production and B cell differentiation toward autoreactive B cells in lupus. These findings reveal that CD38 may promote aberrant inflammation and lupus-like autoimmunity by an apoptosis-driven caspase-3-dependant mechanism. | - |
dc.description.sponsorship | This work was supported in part by the European Commission in collaboration with the following Funding Agencies: Junta de Andalucía (J.A.), Consejería Innovación Ciencia y Empresa y Consejería Educación y Ciencia. Proyecto: PC08-CTS-04046 (J.S. y M.Z.). Ministerio de Economía y Cocmpetitividad (MINECO), Proyecto: SAF-2011-27261 (J.S. y M.Z.). A.R.V. was suported by a felllowship-contract from Consejería de Innovación, Ciencia y Empresa de la Junta de Andalucía. S.G.R. was supported by a JAEDoc contract from CSIC and a MINECO contract. | - |
dc.rights | closedAccess | - |
dc.title | CD38 promotes pristane-induced chronic inflammation and increases susceptibility to experimental lupus by an apoptosis-driven mechanism | - |
dc.type | póster de congreso | - |
dc.date.updated | 2018-05-17T07:57:07Z | - |
dc.description.version | Peer Reviewed | - |
dc.language.rfc3066 | eng | - |
dc.contributor.funder | Junta de Andalucía | - |
dc.contributor.funder | Ministerio de Economía y Competitividad (España) | - |
dc.contributor.funder | Consejo Superior de Investigaciones Científicas (España) | - |
dc.contributor.funder | European Commission | - |
dc.relation.csic | Sí | - |
dc.identifier.funder | http://dx.doi.org/10.13039/501100003329 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100003339 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100000780 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100011011 | es_ES |
dc.type.coar | http://purl.org/coar/resource_type/c_6670 | es_ES |
item.openairetype | póster de congreso | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | none | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | No Fulltext | - |
Aparece en las colecciones: | (IBBTEC) Comunicaciones congresos (IPBLN) Comunicaciones congresos |
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