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Insights into neural oscillations in stress

AutorRaya Salom, D.; Teruel-Martí, Vicent; Cervera-Ferri, Ana; Martínez-Bellver, Sergio; Adell, Albert ; Cors Serra, S.; Martínez-Ricós, Joana
Fecha de publicación2017
EditorSociedad Española de Neurociencia
Citación17 Congreso Nacional de la SENC (2017)
ResumenThe stress system coordinates the adaptive responses of the organism to stressors of any kind. Dysfunction in this circuit may induce disturbances in emotional and cognitive aspects of several stress-related pathologies including depression. Thus, comprehension of dynamics and communication between these structures may lead to better understand neurobiological mechanism underlying anxiety disorders and also the beneficial effects of some treatments, such as deep brain stimulation (DBS). The main purpose of this work is to delve into interactions between several of the structures related to stress control evaluating changes in their oscillatory activity after applying to 2 different models of acute stress. In Experiment 1 Local Field Potentials (LFP) from the infralimbic division of the medial prefrontal cortex (IL), the basolateral division of the amygdala and the dorsal hippocampus, were recorded after the injection of corticotropin releasing hormone (CRH) in the dorsal raphe nucleus (DR). In Experiment 2, we analysed the effects of the electrical activation of the central nucleus of the amygdala (CeA) over the oscillatory dynamics of the IL. In addition, in Experiment 3 the effects of high-frequency electrical stimulation (DBS) targeting the nucleus accumbens core in the oscillatory activity of the infralimbic cortex were examined. Injection of CRH in the DR induced a general activation of the amygdala and the hippocampus, so a significant increment in theta waves power, as well as theta LFP coherence between these structures, was observed. Electrical activation of the CeA caused a delayed but significant change in IL, with prominent slow waves accompanied by an increase in theta activity, coupled with faster oscillations, including gamma and spindles. Interestingly, DBS of nucleus accumbens core generated a similar but not identical slow wave in the IL since spindles were not detected. These results are discussed in terms of processing of the stress response and memory formation.
DescripciónPóster presentado al 17º Congreso Nacional de la Sociedad Española de Neurociencia, celebrado en Alicante del 27 al 30 de septiembre de 2017.
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