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Intratumoral heterogeneity and clonal evolution in blood malignancies and solid tumors

AutorVarela, Ignacio ; Menendez, Pablo; Sanjuan-Pla, Alejandra
Palabras claveCancer genomics
Oncology practice
Intratumoral heterogeneity
Tumor evolution
Bioinformatics
Fecha de publicación2017
EditorImpact Journals
CitaciónOncotarget 8(39): 66742-66746 (2017)
ResumenThis meeting held at the University of Barcelona in March 2017, brought together scientists and clinicians worldwide to discuss current and future clinico-biological implications of intratumoral heterogeneity (ITH) and subclonal evolution in cancer diagnosis, patient stratification, and treatment resistance in diagnosis, treatment and follow-up. There was consensus that both longitudinal and tumor multi-region studies in matched samples are needed to better understand the dynamics of ITH. The contribution of the epigenome and microenvironment to ITH and subclone evolution remains understudied. It was recommended to combine computational, pathology and imaging tools to study the role of the microenvironment in subclone selection/ evolution.
Versión del editorhttps://doi.org/10.18632/oncotarget.20279
URIhttp://hdl.handle.net/10261/164727
Identificadoresdoi: 10.18632/oncotarget.20279
e-issn: 1949-2553
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