English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/164688
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

DC FieldValueLanguage
dc.contributor.authorTejedor, Davides_ES
dc.contributor.authorDelgado-Hernández, Samueles_ES
dc.contributor.authorCarballo, Ruben M.es_ES
dc.contributor.authorDapueto, Rosinaes_ES
dc.contributor.authorMena-Rejón, Gonzalo J.es_ES
dc.contributor.authorGarcía-Tellado, Fernandoes_ES
dc.date.accessioned2018-05-10T11:54:19Z-
dc.date.available2018-05-10T11:54:19Z-
dc.date.issued2017-05-03-
dc.identifier.citationJournal of Organic Chemistry 82(10): 5328-5336 (2017)es_ES
dc.identifier.issn0022-3263-
dc.identifier.urihttp://hdl.handle.net/10261/164688-
dc.description.abstractHerein we describe a salicylaldehyde-annulation reaction as a plug and play toolkit to diversify the complexity of naturally occurring ketones. The protocol entails the transformation of the polycyclic natural ketone into its propargyl vinyl ether derivative (two synthetic steps) and its microwave-assisted imidazole-catalyzed domino rearrangement to generate the salicylaldehyde ring. This annexed unit allows further synthetic transformations: e.g., the installation of a pharmacophore module to generate natural product–pharmacophore hybrids endowed with unknown biological (pharmaceutical) annotations.es_ES
dc.description.sponsorshipThis research was supported by the Spanish Ministerio de Economía y Competitividad (MINECO) and the European Regional Development Fund (CTQ2015-63894-P), the Consejo Superior de Investigaciones Científicas (CSIC) (COOPB20088), and the Mexican CONACYT (CB-2013/22188).es_ES
dc.language.isoenges_ES
dc.publisherAmerican Chemical Societyes_ES
dc.relationMINECO/ICTI2013-2016/CTQ2015-63894-Pes_ES
dc.relation.isversionofPostprint-
dc.rightsopenAccesses_ES
dc.titleDiversifying Complexity by Domino Benzannulation of Polycyclic Natural Productses_ES
dc.typeartículoes_ES
dc.identifier.doi10.1021/acs.joc.7b00654-
dc.description.peerreviewedPeer reviewedes_ES
dc.relation.publisherversionhttp://dx.doi.org/10.1021/acs.joc.7b00654es_ES
dc.identifier.e-issn1520-6904-
dc.contributor.funderMinisterio de Economía y Competitividad (España)es_ES
dc.contributor.funderConsejo Superior de Investigaciones Científicas (España)es_ES
dc.contributor.funderConsejo Nacional de Ciencia y Tecnología (México)es_ES
dc.relation.csices_ES
oprm.item.hasRevisionno ko 0 false*
dc.identifier.funderhttp://dx.doi.org/10.13039/501100003141es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100003339es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100003329es_ES
Appears in Collections:(IPNA) Artículos
Files in This Item:
File Description SizeFormat 
benzannulation_Tejedor.pdf226,87 kBAdobe PDFThumbnail
View/Open
Show simple item record
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.