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Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/164622
Título

Rapid parallel acquisition of somatic mutations after NPM1 in acute myeloid leukaemia evolution

AutorGrove, Carolyn S.; Varela, Ignacio ; Vassiliou, George S.
Palabras claveAcute myeloid leukaemia
Sequencing
Chronic myelomonocytic leukaemia
Clonal evolution
NPM1
Fecha de publicación2017
EditorJohn Wiley & Sons
CitaciónBritish Journal of Haematology 176(5): 825-829 (2017)
ResumenThe steps in the progression from subclinical clonal haemopoiesis to acute myeloid leukaemia (AML) have not been defined, nor has its likelihood or latency. NPM1 mutations were not found to drive clonal haemopoiesis in haematologically normal individuals(Genovese et al, 2014; Jaiswal et al, 2014; Xie et al, 2014; McKerrell et al, 2015), highlighting their strong leukaemogenic pedigree, but making them difficult to capture at a stage prior to frank AML. As occasional cases of NPM1-mutated myelodysplastic syndrome/myeloproliferative neoplasm have been described(Caudill et al, 2006; Peng et al, 2016), we hypothesised that detailed analysis of such cases could offer insights into leukaemic evolution after the acquisition of NPM1 mutations. Here, we describe the genetic events driving rapid progression of a case of NPM1 mutant chronic myelomonocytic leukaemia (CMML) to full-blown AML.
DescripciónCorrespondence.-- Grove, Carolyn S. et al.
URIhttp://hdl.handle.net/10261/164622
Identificadoresdoi: 10.1111/bjh.13999
issn: 0007-1048
e-issn: 1365-2141
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