English   español  
Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/164574
Título

Migration-Selection Balance Drives Genetic Differentiation in GenesAssociatedwithHigh-Altitude Function in the Speckled Teal (Anas flavirostris) in the Andes

AutorGraham, Allie M.; Lavretsky, Philip; Muñoz-Fuentes, Violeta ; Green, Andy J. ; Wilson, Robert E.; McCracken, Kevin G.
Palabras claveLocal adaptation
Hypoxia
Waterfowl
Fecha de publicación2018
EditorOxford University Press
CitaciónGenome biology and evolution, 10(1): 14-32 (2018)
ResumenLocal adaptation frequently occurs across populations as a result of migration-selection balance between divergent selective pressures and gene flow associated with life in heterogeneous landscapes. Studying the effects of selection and gene flow on the adaptation process can be achieved in systemsthat have recently colonized extremeenvironments. This study utilizes an endemic South American duck species, the speckled teal (Anas flavirostris),which has both high- and low-altitude populations. High-altitude speckled teal (A. f. oxyptera) are locally adapted to the Andean environment and mostly allopatric from low-altitude birds (A. f. flavirostris);however, there is occasional geneflowacross altitudinal gradients. In this study,we used next-generation sequencing to explore genetic patterns associated with high-altitude adaptation in speckled teal populations, as well as the extent to which the balance between selection and migration have affected genetic architecture. We identified a set of loci with allele frequencies strongly correlated with altitude, including those involved in the insulin-like signaling pathway, bone morphogenesis, oxidative phosphorylation, responders to hypoxia-induced DNAdamage, and feedback loops to the hypoxia-inducible factor pathway. These same outlier loci were found to have depressed gene flow estimates, as well as being highly concentrated on the Z-chromosome. Our results suggest a multifactorial response to life at high altitudes through an array of interconnected pathways that are likely under positive selection and whose genetic components seem to be providing an effective genomic barrier to interbreeding, potentially functioning as an avenue for population divergence and speciation
Versión del editorhtpp://dx.doi.org/10.1093/gbe/evx253
URIhttp://hdl.handle.net/10261/164574
DOI10.1093/gbe/evx253
Aparece en las colecciones: (EBD) Artículos
Ficheros en este ítem:
Fichero Descripción Tamaño Formato  
evx253.pdf1,06 MBAdobe PDFVista previa
Visualizar/Abrir
Mostrar el registro completo
 

Artículos relacionados:


NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.