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Título: | HOX13 proteins: the molecular switcher in Hoxd bimodal regulation |
Autor: | Ros, María A. CSIC ORCID | Fecha de publicación: | 2016 | Editor: | Cold Spring Harbor Laboratory Press | Citación: | Genes and Development 30(10): 1135-1137 (2016) | Resumen: | The striking correlation between the genomic arrangement of Hox genes and their temporal and spatial pattern of expression during embryonic development has been a source of fascination since its discovery. This correspondence has been used as a privileged example in the investigation of the connection between genomic architecture and function. In this issue of Genes & Development, Beccari and colleagues (pp. 1172-1186) make a big step forward in understanding Hox gene regulation during limb development by showing the pivotal role of HOXA13 and HOXD13 proteins in the transition from a proximal to a distal type of Hoxd transcriptional regulation. | Versión del editor: | https://doi.org/10.1101/gad.283598.116 | URI: | http://hdl.handle.net/10261/164506 | DOI: | 10.1101/gad.283598.116 | Identificadores: | doi: 10.1101/gad.283598.116 issn: 0890-9369 e-issn: 1549-5477 |
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hox13regula.pdf | 317,09 kB | Adobe PDF | Visualizar/Abrir |
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