Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/164461
COMPARTIR / EXPORTAR:
logo share SHARE logo core CORE BASE
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE

Invitar a revisión por pares abierta
Título

Characterization of oscillatory changes in hippocampus and amygdala after deep brain stimulation of the infralimbic prefrontal cortex

AutorCervera-Ferri, Ana; Teruel-Martí, Vicent; Barceló-Molina, Moises; Martínez-Ricós, Joana; Luque-García, Aina; Martínez-Bellver, Sergio; Adell, Albert CSIC ORCID
Palabras claveMutual information
Modulatory index
Local field potential
Brain oscillations
Antidepressant
Fecha de publicación2016
EditorJohn Wiley & Sons
Physiological Society (Great Britain)
American Physiological Society
CitaciónPhysiological Reports 4(14): e12854 (2016)
ResumenDeep brain stimulation (DBS) is a new investigational therapy that has generated positive results in refractory depression. Although the neurochemical and behavioral effects of DBS have been examined, less attention has been paid to the influence of DBS on the network dynamics between different brain areas, which could contribute to its therapeutic effects. Herein, we set out to identify the effects of 1 h DBS in the infralimbic cortex (IL) on the oscillatory network dynamics between hippocampus and basolateral amygdala (BLA), two regions implicated in depression and its treatment. Urethane-anesthetized rats with bilaterally implanted electrodes in the IL were exposed to 1 h constant stimulation of 130 Hz of frequency, 60 μA of constant current intensity and biphasic pulse width of 80 μsec. After a period of baseline recording, local field potentials (LFP) were recorded with formvar-insulated stainless steel electrodes. DBS of the IL increased the power of slow wave (SW, <1.5 Hz) and theta (3–12 Hz) frequencies in the hippocampus and BLA. Furthermore, IL DBS caused a precise coupling in different frequency bands between both brain structures. The increases in SW band synchronization in hippocampus and BLA after DBS suggest that these changes may be important for the improvement of depressive behavior. In addition, the augmentation in theta synchrony might contribute to improvement in emotional and cognitive processes.
Versión del editorhttps://doi.org/10.14814/phy2.12854
URIhttp://hdl.handle.net/10261/164461
DOI10.14814/phy2.12854
Identificadoresdoi: 10.14814/phy2.12854
e-issn: 2051-817X
Aparece en las colecciones: (IBBTEC) Artículos




Ficheros en este ítem:
Fichero Descripción Tamaño Formato
chaprecortex.pdf2,41 MBAdobe PDFVista previa
Visualizar/Abrir
Mostrar el registro completo

CORE Recommender

PubMed Central
Citations

7
checked on 10-abr-2024

SCOPUSTM   
Citations

14
checked on 17-abr-2024

WEB OF SCIENCETM
Citations

12
checked on 22-ene-2024

Page view(s)

302
checked on 18-abr-2024

Download(s)

212
checked on 18-abr-2024

Google ScholarTM

Check

Altmetric

Altmetric


Artículos relacionados:


Este item está licenciado bajo una Licencia Creative Commons Creative Commons