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Picogram per liter level determination of estrogens in natural waters and waterworks by a fully automated on-line solid-phase extraction-liquid chromatography-electrospray tandem mass spectrometry method

AutorRodríguez-Mozaz, Sara; López de Alda, Miren; Barceló, Damià
Palabras claveSolid-phase extraction-liquid chromatography-electrospray tandem mass spectrometry
Estrogenic properties
Estrogens in water
Llobregat River
Fecha de publicación26-oct-2004
EditorAmerican Chemical Society
CitaciónAnalytical Chemistry 76(23): 6998–7006 (2004)
ResumenThe present work describes a novel, fully automated method, based on on-line solid-phase extraction-liquid chromatography-electrospray tandem mass spectrometry (SPE-LC-ESI-MS-MS), which allows the unequivocal identification and quantification of the most environmentally relevant estrogens (estradiol, estrone, estriol, estradiol-17-glucuronide, estradiol-17-acetate, estrone-3-sulfate, ethynyl estradiol, diethylstilbestrol) in natural and treated waters at levels well below those of concern (limits of quantification between 0.02 and 1.02 ng/L). The method is highly precise, with relative standard deviations varying between 1.43 and 3.89%, and accurate (recovery percentages >74 %). This method was used to track the presence and fate of the target compounds in a waterworks and to evaluate the removal efficiency of the treatment processes applied. Only estrone and estrone-3-sulfate were detected in the river water used as source (at 0.68 and 0.33 ng/L, respectively). After progressive removal through the various treatment steps, none of them were detected in the finished drinking water. In addition to selectivity, sensitivity, repeatability, and automation (up to 15 samples plus 6 calibration solutions and 1 blank can be analyzed unattended), this technique offers fairly high throughput (analysis time per sample is 60 min), low time and solvent consumption, and ease of use.
Descripción9 pages, 6 figures, 3 tables.-- PMID: 15571352 [PubMed].-- Printed version published Dec 1, 2004.
Versión del editorhttp://dx.doi.org/10.1021/ac049051v
ISSN0003-2700 (Print)
1520-6882 (Online)
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