English   español  
Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/164328
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

Solvent-assisted in situ synthesis of cysteamine-capped silver nanoparticles

AutorOliva, José M. ; Ríos de la Rosa, Julio M.; Sayagués, María Jesús ; Sánchez-Alcázar, José Antonio ; Merkling, Patrick J.; Zaderenko, Ana P.
Palabras claveCysteamine
Silver nanoparticles
Targeted antitumor therapy
Epidermal growth factor receptor
Fecha de publicación2018
EditorInstitute of Physics Publishing
CitaciónAdvances in Natural Sciences: Nanoscience and Nanotechnology, 9 (2018)
ResumenSilver nanoparticles offer a huge potential for biomedical applications owing to their exceptional properties and small size. Specifically, cysteamine-capped silver nanoparticles could form the basis for new anticancer therapies combining the cytotoxic effect of the silver core with the inherent antitumor activity of cysteamine, which inhibit cancer cell proliferation and suppress invasion and metastasis. In addition, the capability of the cysteamine coating monolayer to couple a variety of active principles and targeting (bio)molecules of interest proves key to the tailoring of this platform in order to exploit the pathophysiology of specific tumor types. Nevertheless, the chain length and conformational flexibility of cysteamine, together with its ability to attach to the surface of silver nanoparticles via both the thiol and the amine group, have made the in situ synthesis of these particles an especially challenging task. Herein we report a solvent-assisted in situ synthesis method that solves this problem. The obtained nanoparticles have been fully characterized by UV–visible absorption spectroscopy, Fourier transform infrared spectroscopy, transmission electron microscopy, electron diffraction measurement, high resolution transmission electron microscopy, scanning transmission electron microscopy, energy dispersive x-ray spectroscopy nanoanalysis, and dynamic light scattering measurement. Our synthesis method achieves extremely high yield and surface coating ratio, and colloidal stability over a wide range of pH values including physiological pH. Additionally, we have demonstrated that cysteamine-capped nanoparticles obtained by this method can be conjugated to an antibody for active targeting of the epidermal growth factor receptor, which plays an important role in the pathogenesis and progression of a wide variety of tumors, and induce cell death in human squamous carcinoma cells. We believe this method can be readily extended to combinations of noble metals and longer chain primary, secondary, ternary or even quaternary aminethiols
Versión del editorhttps://doi.org/10.1088/2043-6254/aa9de9
Aparece en las colecciones: (ICMS) Artículos
Ficheros en este ítem:
Fichero Descripción Tamaño Formato  
Oliva_2018_Adv._Nat._Sci%3A_Nanosci._Nanotechnol._9_015001.pdf1,72 MBAdobe PDFVista previa
Mostrar el registro completo

NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.