Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/164285
Share/Export:
logo share SHARE logo core CORE BASE
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE
Title

Cannabidiol induces rapid-acting antidepressant-like effects and enhances cortical 5-HT/glutamate neurotransmission: role of 5-HT1A receptors

AuthorsLinge, Raquel CSIC; Jiménez-Sánchez, Laura CSIC; Campa, Leticia CSIC ORCID; Pilar-Cuéllar, Fuencisla CSIC ORCID; Vidal, Rebeca CSIC ORCID; Pazos, Ángel CSIC ORCID; Adell, Albert CSIC ORCID ; Díaz, Álvaro CSIC ORCID
KeywordsSerotonin
5-HT1A receptor
Olfactory bulbectomy
Glutamate
Antidepressant
Cannabidiol
Issue Date2016
PublisherElsevier
CitationNeuropharmacology 103: 16-26 (2016)
AbstractCannabidiol (CBD), the main non-psychotomimetic component of marihuana, exhibits anxiolytic-like properties in many behavioural tests, although its potential for treating major depression has been poorly explored. Moreover, the mechanism of action of CBD remains unclear. Herein, we have evaluated the effects of CBD following acute and chronic administration in the olfactory bulbectomy mouse model of depression (OBX), and investigated the underlying mechanism. For this purpose, we conducted behavioural (open field and sucrose preference tests) and neurochemical (microdialysis and autoradiography of 5-HT receptor functionality) studies following treatment with CBD. We also assayed the pharmacological antagonism of the effects of CBD to dissect out the mechanism of action. Our results demonstrate that CBD exerts fast and maintained antidepressant-like effects as evidenced by the reversal of the OBX-induced hyperactivity and anhedonia. In vivo microdialysis revealed that the administration of CBD significantly enhanced serotonin and glutamate levels in vmPFCx in a different manner depending on the emotional state and the duration of the treatment. The potentiating effect upon neurotransmitters levels occurring immediately after the first injection of CBD might underlie the fast antidepressant-like actions in OBX mice. Both antidepressant-like effect and enhanced cortical 5-HT/glutamate neurotransmission induced by CBD were prevented by 5-HT receptor blockade. Moreover, adaptive changes in pre- and post-synaptic 5-HT receptor functionality were also found after chronic CBD. In conclusion, our findings indicate that CBD could represent a novel fast antidepressant drug, via enhancing both serotonergic and glutamate cortical signalling through a 5-HT receptor-dependent mechanism.
Publisher version (URL)https://doi.org/10.1016/j.neuropharm.2015.12.017
URIhttp://hdl.handle.net/10261/164285
DOI10.1016/j.neuropharm.2015.12.017
Identifiersdoi: 10.1016/j.neuropharm.2015.12.017
e-issn: 1873-7064
issn: 0028-3908
Appears in Collections:(IIBB) Artículos
(IBBTEC) Artículos

Files in This Item:
File Description SizeFormat
cannabidiolreceptor.pdf353,77 kBAdobe PDFThumbnail
View/Open
Show full item record
Review this work

PubMed Central
Citations

59
checked on Jan 27, 2022

SCOPUSTM   
Citations

135
checked on Jan 25, 2022

WEB OF SCIENCETM
Citations

128
checked on Jan 25, 2022

Page view(s)

431
checked on Jan 27, 2022

Download(s)

1,458
checked on Jan 27, 2022

Google ScholarTM

Check

Altmetric

Dimensions


Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.