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Title

The gene regulatory network underpinning dorsal-ventral pigmentation patterning in fish. Analysis of agouti cis-regulatory landscape

AuthorsCal, Laura; Braash, I.; Gómez-Skarmeta, José Luis ; Kelsh, R.; Cerdá-Reverter, José Miguel ; Rotllant, Josep
Issue Date2017
PublisherUniversidad Jaume I
CitationAdvances in Comparative Endocrinology VIII: 119-122 (2017)
AbstractDorso-ventral pigment pattern differences are the most widespread pigmentary adaptations in vertebrates. In mammals, agouti-signaling protein (ASIP) have been reported as the key factor in this process by regulating melanin types and levels in melanocytes. In fish, studies of pigment patterning have focused on stripe formation, identifying a core striping mechanism dependent upon interactions between different pigment cell types. We have recently demonstrated thatzebrafish utilize two distinct adult pigment patterning mechanisms -an ancient dorso-ventral patterning mechanism, and a more recent striping mechanism based on cell-cell interactions; remarkably, the dorso-ventral patterning mechanism also utilizes Asip. We hypothesize that Asip have a conserved role in the countershading pigment pattern formation in vertebrates. However, the molecular and cellular mechanisms underlying this dorso-ventral asip1 expression gradient remain largely unexplored. We report here the asip expression in the holostei spotted gar (Lepisosteus oculatus), one of Darwin's defining examples of 'living fossils'. Using phylogenetic footprinting and transgenesis in zebrafish, we examine the conserved cis-regulatory elements surrounding agouti gene.
DescriptionPonencia presentada en el 10º Congreso de la Asociación Ibérica de Endocrinología Comparada (AIEC), celebrado en la Universidad Jaume I (Castellón, España) del 23 al 25 de septiembre de 2015.
URIhttp://hdl.handle.net/10261/164145
Identifiersisbn: 978-84-16356-88-1
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