Larval density during L1 arrest impacts recovery from starvation through changes in DAF-16 nuclear localization

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Campo DC	Valor	Lengua/Idioma
dc.contributor.author	Olmedo, María	es_ES
dc.contributor.author	Rodríguez-Palero, María Jesús	es_ES
dc.contributor.author	Fernández-Yáñez, Antonio	es_ES
dc.contributor.author	Merrow, Martha	es_ES
dc.contributor.author	Artal-Sanz, Marta	es_ES
dc.date.accessioned	2018-04-24T09:03:57Z	-
dc.date.available	2018-04-24T09:03:57Z	-
dc.date.issued	2017	-
dc.identifier.citation	21st International C. elegans Conference (2017)	es_ES
dc.identifier.uri	http://hdl.handle.net/10261/164072	-
dc.description	Resumen del trabajo presentado a la 21st International C. elegans Conference of the Genetics Society of America, celebrada en California, Los Angeles (US) del 21 al 25 de junio de 2017.-- et al.	es_ES
dc.description.abstract	The developmental progression of Caenorhabditis elegans can be slowed down or interrupted when animals face unfavourable conditions like food scarcity. C. elegans larvae arrest as L1s when hatching in the absence of food. Arrested L1s can survive several weeks without food and present increased resistance to stress. Several genetic and environmental factors impact the survival of arrested L1s. These include the Insulin/insulin-like growth factor signalling (IIS) pathway and larval density during arrest. The effect of density is mediated by exposure of unknown compounds secreted after hatching. When food becomes available, larvae resume postembryonic development but animals that have been starved for long periods of time take longer to reach adulthood. This effect of starvation was attributed to a developmental delay after extended starvation. However, using a method we developed to measure developmental timing we have been able to measure the duration of each stage of development after extended starvation. We have observed that developmental speed is resilient to time in starvation. The later entry into adulthood after extended arrest corresponds, instead, with a delay to resume development. That is, extended starvation increases recovery time. Using the same method, we observe that recovery time is affected by interventions that affect survival to starvation, like mutations in the IIS pathway and density of animals during arrest. In addition, we show that high density of animals contributes to the maintenance of DAF-16 nuclear localization during arrest, contributing to longer survival and fast recovery from arrest. Our results indicate that density and low insulin signalling impact DAF-16 function in a similar manner, possibly allowing integration of the two signals to control developmental arrest.	es_ES
dc.language.iso	eng	es_ES
dc.rights	closedAccess	es_ES
dc.title	Larval density during L1 arrest impacts recovery from starvation through changes in DAF-16 nuclear localization	es_ES
dc.type	comunicación de congreso	es_ES
dc.description.peerreviewed	Peer reviewed	es_ES
dc.relation.csic	Sí	es_ES
oprm.item.hasRevision	no ko 0 false	*
dc.type.coar	http://purl.org/coar/resource_type/c_5794	es_ES
item.languageiso639-1	en	-
item.fulltext	No Fulltext	-
item.openairecristype	http://purl.org/coar/resource_type/c_18cf	-
item.cerifentitytype	Publications	-
item.grantfulltext	none	-
item.openairetype	comunicación de congreso	-
Aparece en las colecciones:	(CABD) Comunicaciones congresos