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Title

Larval density during L1 arrest impacts recovery from starvation through changes in DAF-16 nuclear localization

AuthorsOlmedo, María; Rodríguez-Palero, María Jesús ; Fernández-Yáñez, Antonio; Merrow, Martha; Artal-Sanz, Marta
Issue Date2017
Citation21st International C. elegans Conference (2017)
AbstractThe developmental progression of Caenorhabditis elegans can be slowed down or interrupted when animals face unfavourable conditions like food scarcity. C. elegans larvae arrest as L1s when hatching in the absence of food. Arrested L1s can survive several weeks without food and present increased resistance to stress. Several genetic and environmental factors impact the survival of arrested L1s. These include the Insulin/insulin-like growth factor signalling (IIS) pathway and larval density during arrest. The effect of density is mediated by exposure of unknown compounds secreted after hatching. When food becomes available, larvae resume postembryonic development but animals that have been starved for long periods of time take longer to reach adulthood. This effect of starvation was attributed to a developmental delay after extended starvation. However, using a method we developed to measure developmental timing we have been able to measure the duration of each stage of development after extended starvation. We have observed that developmental speed is resilient to time in starvation. The later entry into adulthood after extended arrest corresponds, instead, with a delay to resume development. That is, extended starvation increases recovery time. Using the same method, we observe that recovery time is affected by interventions that affect survival to starvation, like mutations in the IIS pathway and density of animals during arrest. In addition, we show that high density of animals contributes to the maintenance of DAF-16 nuclear localization during arrest, contributing to longer survival and fast recovery from arrest. Our results indicate that density and low insulin signalling impact DAF-16 function in a similar manner, possibly allowing integration of the two signals to control developmental arrest.
DescriptionResumen del trabajo presentado a la 21st International C. elegans Conference of the Genetics Society of America, celebrada en California, Los Angeles (US) del 21 al 25 de junio de 2017.-- et al.
URIhttp://hdl.handle.net/10261/164072
Appears in Collections:(CABD) Comunicaciones congresos
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