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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Romero, Antonia M. | es_ES |
dc.contributor.author | Jordá, Tania | es_ES |
dc.contributor.author | Rozès, Nicolas | es_ES |
dc.contributor.author | Martínez-Pastor, María Teresa | es_ES |
dc.contributor.author | Puig, Sergi | es_ES |
dc.date.accessioned | 2018-04-23T09:29:23Z | - |
dc.date.available | 2018-04-23T09:29:23Z | - |
dc.date.issued | 2018-04-05 | - |
dc.identifier.citation | Biochimica et Biophysica Acta-Molecular and Cell Biology of Lipids 1863 (6): 657-668 (2018) | es_ES |
dc.identifier.issn | 1388-1981 | - |
dc.identifier.uri | http://hdl.handle.net/10261/164001 | - |
dc.description.abstract | Unsaturated fatty acids (UFA) are essential components of phospholipids that greatly contribute to the biophysical properties of cellular membranes. Biosynthesis of UFAs relies on a conserved family of iron-dependent fatty acid desaturases, whose representative in the model yeast Saccharomyces cerevisiae is Ole1. OLE1 expression is tightly regulated to adapt UFA biosynthesis and lipid bilayer properties to changes in temperature, and in UFA or oxygen availability. Despite iron deficiency being the most extended nutritional disorder worldwide, very little is known about the mechanisms and the biological relevance of fatty acid desaturases regulation in response to iron starvation. In this report, we show that endoplasmic reticulum-anchored transcription factor Mga2 activates OLE1 transcription in response to nutritional and genetic iron deficiencies. Cells lacking MGA2 display low UFA levels and do not grow under iron-limited conditions, unless UFAs are supplemented or OLE1 is overexpressed. The proteasome, E3 ubiquitin ligase Rsp5 and the Cdc48Npl4/Ufd1 complex are required for OLE1 activation during iron depletion. Interestingly, Mga2 also activates the transcription of its own mRNA in response to iron deficiency, hypoxia, low temperature and low UFAs. MGA2 up-regulation contributes to increase OLE1 expression in these situations. These results reveal the mechanism of OLE1 regulation when iron is scarce and identify the MGA2 auto-regulation as a potential activation strategy in multiple stresses. | es_ES |
dc.description.sponsorship | This work was supported by the predoctoral contract BES-2012-055637 from the Spanish Ministry of Economy, Industry and Competitiveness to Antonia M. Romero; and the Spanish Ministry of Economy, Industry and Competitiveness grants BIO2014-56298-P and BIO2017-87828-C2-1-P, and FEDER (Fondo Europeo de Desarrollo Regional) funds to Sergi Puig. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Elsevier | es_ES |
dc.relation | info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/BIO2014-56298-P | es_ES |
dc.relation | info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/BIO2017-87828-C2-1-P | es_ES |
dc.relation.isversionof | Postprint | es_ES |
dc.rights | openAccess | en_EN |
dc.subject | Yeast | es_ES |
dc.subject | Saccharomyces cerevisiae | es_ES |
dc.subject | Iron deficiency | es_ES |
dc.subject | Fatty acids | es_ES |
dc.subject | Ole1 | es_ES |
dc.subject | Mga2 | es_ES |
dc.subject | Hypoxia | es_ES |
dc.subject | Cold | es_ES |
dc.title | Regulation of yeast fatty acid desaturase in response to iron deficiency | es_ES |
dc.type | artículo | es_ES |
dc.identifier.doi | 10.1016/j.bbalip.2018.03.008 | - |
dc.description.peerreviewed | Peer reviewed | es_ES |
dc.relation.publisherversion | https://doi.org/10.1016/j.bbalip.2018.03.008 | es_ES |
dc.embargo.terms | 2019-04-05 | es_ES |
dc.rights.license | http://creativecommons.org/licenses/by-nc-nd/4.0/ | es_ES |
dc.contributor.funder | Ministerio de Economía y Competitividad (España) | es_ES |
dc.contributor.funder | European Commission | es_ES |
dc.relation.csic | Sí | es_ES |
oprm.item.hasRevision | no ko 0 false | * |
dc.identifier.funder | http://dx.doi.org/10.13039/501100003329 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100000780 | es_ES |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairetype | artículo | - |
item.grantfulltext | open | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | With Fulltext | - |
item.languageiso639-1 | en | - |
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BBA-2018-Romero.pdf | Artículo principal | 1,03 MB | Adobe PDF | Visualizar/Abrir |
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