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Biophysical constraints drive three-dimensional architecture in epithelial organs

AutorGómez-Gálvez, Pedro; Valencia-Expósito, Andrea; Martín-Bermudo, María D. ; Escudero, Luis M.
Fecha de publicación2017
CitaciónFEBS3+ (2017)
XL SEBBM Congress (2017)
ResumenAs animals develop, the initial simple planar epithelia of embryos must be sculpted into complex three-dimensional tissues. Epithelial bending is therefore a general principle of all developing systems. Here we use different geometrical and biophysical models to analyse three-dimensional packing in curved structures. We fi nd that under specific circumstances tissue bending induces a neighbour exchange along the apico-basal axis of epithelial cells. This causes cells participating in these crucial motifs to adopt an undescribed geometrical confi guration that we name “scutoids”. Strikingly, analyses of different curved tissues and glands confirm the apparition of scutoids during morphogenesis. Using simple geometrical and biophysical concepts we are able to predict the emergence of scutoids. We conclude that the generation of the previously unnoticed scutoids is necessary for the bending of the tissue. Our fi ndings pave the way for understanding how epithelial structures such as glands and organs are formed and maintained.
DescripciónResumen del póster presentado al 1st Joint Meeting of the French-Portuguese-Spanish Biochemical and Molecular Biology Societies y al XL Spanish Society of Biochemistry and Molecular Biology (SEBBM) Congress, celebrado en Barcelona (España) del 23 al 26 de octubre de 2017.-- et al.
Aparece en las colecciones: (CABD) Comunicaciones congresos
(IBIS) Comunicaciones congresos
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