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Unexpected similarities found between the membrane coat proteins based on structural comparisons

AutorGutiérrez, Fernando I.; Devos, Damien P.; Melo, Francisco
Fecha de publicación2017
CitaciónFEBS3+ (2017)
XL SEBBM Congress (2017)
ResumenMembrane coat proteins (MC) are essential for intracellular traffic and they predominate in the eukaryotic endomembrane system. Phylogenetic and comparative genomic analyses have suggested that MC proteins arose by duplication and divergence from the trafficking machinery that was present in the Last Eukaryotic Common Ancestor (LECA). The “protocoatomer” hypothesis suggests that these proteins share a common ancestor based on structural information. However, the MC proteins display a wide variety of forms and a large sequence divergence among them, which makes diffi cult the reconstruction of the evolutionary intermediate steps of the MC proteins with the current comparison tools based on structural and sequence alignments. We previously developed an effi cient computer program, called MOMA (for MOrphing & MAtching) to achieve a flexible and global comparison of protein structures based on matrices of the secondary structure elements (Gutiérrez et al., 2016). We have developed a new methodology to evaluate the significance of local structural alignments found with MOMA based on comparison of homologous and analogous examples and machine learning. Various additional tools are then used to improve superposition and the best combination of the local alignments. Finally, we propose a new score to calculate the average significance of alignments generated with MOMA. Application of our method allowed us to confirm the known relationships previously described in the literature and also revealed unexpected new relations among the MC proteins. Our results support the evolution of the protocoatomers by duplication and divergence, thus reinforcing the proposal that the MC proteins have played an important role in the emergence of the complexity in eukaryotic cells.
DescripciónResumen del póster presentado al 1st Joint Meeting of the French-Portuguese-Spanish Biochemical and Molecular Biology Societies y al XL Spanish Society of Biochemistry and Molecular Biology (SEBBM) Congress, celebrado en Barcelona (España) del 23 al 26 de octubre de 2017.
URIhttp://hdl.handle.net/10261/163949
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