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Recent evolution of the epigenomic landscape in human and other primates

AuthorsGarcía-Pérez, Raquel; Riera, Meritxell; Gómez-Skarmeta, José Luis ; Juan, David; Marqués-Bonet, Tomàs
Issue Date2017
CitationFEBS3+ (2017)
XL SEBBM Congress (2017)
AbstractEvolutionary biologists have long sought to discern the molecular basis of phenotypic variation. Changes in chromatin structure and gene regulation are thought to play a major role in evolution and speciation, particularly in primates. Nevertheless, we still know little about the evolution of regulatory mechanisms in diff erent species. As a result, over the last decade, the fi eld has experienced a major shift towards inter-species comparative epigenomics in search of a conceptual step-forward in our understanding of evolution. Our study aims to establish the basis for a more comprehensive understanding of the evolutionary dynamics of regulatory elements in the primate lineage at a fine scale. To that end, we have extensively profi led lymphoblastoid cell lines (LCLs) from human, chimpanzee, gorilla, orangutan and macaque. This epigenomic characterization includes whole genome sequencing data, whole genome bisulfi te data, deep-transcriptome sequencing data, chromatin accessibility data (ATAC-seq) as well as ChIP-seq data from five key histone modifications (H3K4me1, H3K4me3, H3K36me3, H3K27ac and H3K27me3) and CTCF. We are taking advantage of these data to: 1) improve the annotation of cis-regulatory elements, particularly for the non-human species; 2) investigate the contribution of inter-species differences in methylation levels and histone modifi cations to gene expression variation; 3) understand how the interplay between different regulatory elements evolves in the different lineages; 4) study how the interplay between regulatory and sequence evolution shapes different phenotypic scenarios in a lineage-specific manner. The results of this work will contribute to enlighten human specific molecular innovations and will improve our understanding of recent genome evolution providing also a valuable interdisciplinary resource of major interest for the scientific community.
DescriptionResumen del póster presentado al 1st Joint Meeting of the French-Portuguese-Spanish Biochemical and Molecular Biology Societies y al XL Spanish Society of Biochemistry and Molecular Biology (SEBBM) Congress, celebrado en Barcelona (España) del 23 al 26 de octubre de 2017.-- et al.
Appears in Collections:(CABD) Comunicaciones congresos
(IBE) Comunicaciones congresos
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