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Rhizoctonia solani fucomannogalactan: Chemical characterization and antiproliferative activity

AutorAlexandre, Samara M. A.; Corradi da Silva, Maria de Lourdes; Vasconcelos, Ana F. D.; Exposti, Diego T. D.; Tischer, Cesar A.; Prieto, Alicia ; Diaz Hernandez, Maria Dolores; Kaneno, Ramon
Palabras claveAntiproliferative activity
Fucomannogalactan
Gel filtration chromatography
NMR spectroscopy
Rhizoctonia solani
Fecha de publicación10-abr-2018
EditorElsevier
CitaciónInt J Biol Macromol S0141-8130(17)34829-8 (2018)
ResumenA fucomannogalactan from Rhizoctonia solani biomass was obtained after hot aqueous extraction and purified by freeze-thaw cycles and gel filtration chromatography on Sepharose CL-6B. The polysaccharide was homogeneous after HPSEC/RID analysis (Mw/Mn ~ 1.1), displaying an average molecular weight of 15.4 × 103 Da. Its chemical structure was determined by methylation analysis (GC/MS) and spectroscopy (FTIR, 1D and 2D NMR). The polysaccharide had a branched α-1,6-linked Galp backbone with 66% linear residues, a number of which were at O-3 methylated. Side chains (34%) were always linked at O-2 positions of the main chain and consisted of single, non-reducing ends of α-d-Manp (6%) and α-l-Fucp (28%). Analysis of its biological activity showed that the highly purified fucomannogalactan from R. solani inhibited the proliferation of colon cancer cells in vitro, but that it did not have the same activity against lung cancer cells.
Descripción23 p.-7 fig.-2 tab.-1 graph. abst.
Versión del editorhttp://dx.doi.org/10.1016/j.ijbiomac.2018.04.035
URIhttp://hdl.handle.net/10261/163843
DOI10.1016/j.ijbiomac.2018.04.035
ISSN0141-8130
E-ISSN1879-0003
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