English   español  
Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/163731
Compartir / Impacto:
Estadísticas
Add this article to your Mendeley library MendeleyBASE
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Título

Molecular and cellular mechanisms controlling cell rearrangement during development

AutorMolina Gil, Sara; Espinosa-Vázquez, José Manuel; Castelli-Gair Hombría, James
Fecha de publicación2016
EditorSociedad Española de Biología Celular
Citación11th Meeting SEBD (2016)
ResumenThe process of organogenesis involves several morphogenetic mechanisms that are coordinated by gene networks controlling the different cell behaviours during development. Due to the complexity of this process we concentrate on the study of a simple epithelial organ, the posterior spiracles, of Drosophila melanogaster. This model allows us to study the cell shape changes and cell rearrangements that occur in its formation. The HOX gene Abd-B induces a gene network that coordinates in the 8th abdominal segment (A8) the formation of the two structures forming the posterior spiracles: the spiracular chamber and the stigmatophore. The stigmatophore is the only engrailed-expressing circumferential structure of the embryo. Here we studied how the early segmentation pattern that subdivides the embryo in identical stripes of cells evolves into a circumferential pattern mediated by Abd-B activation of the Spalt gene. Spalt re-specifies anterior compartment cells in the A8 segment, activating the polarity gene engrailed to create the circumferential structure. We have found this is achieved through several spiracle specific spalt and engrailed enhancers that respond to different signals transforming the stripe information into circumferential information. We propose that Spalt homogenizes the stigmatophore positional information by activating engrailed in both anterior and posterior compartment cells, providing all stigmatophore cells with a similar positional and morphogenetic behaviour. Therefore, this work is focused on finding out how spalt expression in the stigmatophore is activated and how spalt directs the cell rearrangement to create a circumferential structure.
DescripciónResumen del póster presentado al 11th Meeting of the Spanish Society for Developmental Biology, celebrado en Girona (España) del 19 al 21 de octubre de 2016.
URIhttp://hdl.handle.net/10261/163731
Aparece en las colecciones: (CABD) Comunicaciones congresos
Ficheros en este ítem:
Fichero Descripción Tamaño Formato  
accesoRestringido.pdf15,38 kBAdobe PDFVista previa
Visualizar/Abrir
Mostrar el registro completo
 


NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.