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Analysis of YAP/TAZ-dependent transcriptional response during epithelial morphogenesis in teleost embryos

AutorVázquez-Marín, Javier; Letelier, Joaquin; Buono, Lorena ; Wittbrodt, Joachim; Martínez-Morales, Juan Ramón
Fecha de publicación2016
EditorSociedad Española de Biología Celular
Citación11th Meeting SEBD (2016)
ResumenThe Hippo signaling pathway is a genetic regulatory cascade that controls tissue homeostasis and organ size by coordinating the expression of proliferation, differentiation and apoptotic genes during development. The main constituent of this pathway is an effector complex, composed of paralog proteins YAP and TAZ. When YAP/TAZ is active, it gets into the cell nucleus and regulates the expression of its target genes interacting physically with TEAD, among other transcription factors. YAP/TAZ activity is regulated by many external factors, among which stand out mechanical cues. When the cell senses these signals, YAP/TAZ protein complex gets translocated into the nucleus where it plays its transcriptional role. During the gastrulation of teleosts, several morphogenetic movements including convergent-extension and cell involution direct the formation of the basic body plan. This complex choreography entitles the generation and transmission of mechanical tensions. In fact, our imaging results suggest a link between morphogenetic tension and nuclear translocation of YAP in gastrulating cells in zebrafish embryos. The aim of this project is to investigate the role that those mechanical cues play on the YAP/TAZ complex and to analyse its transcriptional outcome during gastrulation. To understand YAP/TAZ-dependent transcriptional response, we have analysed the binding of these factors to the genome using an iDamID-seq approach both in zebrafish and medaka embryos. The computational analysis of this data set, in combination with a RNA-seq transcriptomic profiling of mutant embryos for YAP/TAZ, will allow defining downstream targets controlled by the Hippo pathway in the morphogenetic context of a gastrulating embryo.
DescripciónResumen del póster presentado al 11th Meeting of the Spanish Society for Developmental Biology, celebrado en Girona (España) del 19 al 21 de octubre de 2016.-- et al.
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