English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/163631
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

Title

From top to bottom: Cell polarity in Hedgehog and Wnt trafficking

AuthorsGradilla, Ana-Citlali ; Sánchez-Hernández, David ; Brunt, Lucy; Scholpp, Steffen
Issue Date10-Apr-2018
PublisherBioMed Central
CitationBMC Biology 16(1): 37 (2018)
AbstractAbstract Spatial organization of membrane domains within cells and cells within tissues is key to the development of organisms and the maintenance of adult tissue. Cell polarization is crucial for correct cell–cell signalling, which, in turn, promotes cell differentiation and tissue patterning. However, the mechanisms linking internal cell polarity to intercellular signalling are just beginning to be unravelled. The Hedgehog (Hh) and Wnt pathways are major directors of development and their malfunction can cause severe disorders like cancer. Here we discuss parallel advances into understanding the mechanism of Hedgehog and Wnt signal dissemination and reception. We hypothesize that cell polarization of the signal-sending and signal-receiving cells is crucial for proper signal spreading and activation of the pathway and, thus, fundamental for development of multicellular organisms.
Publisher version (URL)https://doi.org/10.1186/s12915-018-0511-x
URIhttp://hdl.handle.net/10261/163631
DOI10.1186/s12915-018-0511-x
Appears in Collections:(CBM) Artículos
Files in This Item:
File Description SizeFormat 
12915_2018_Article_511.pdf1,26 MBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.