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dc.contributor.authorSalas-Pino, Silvia-
dc.contributor.authorGallardo, Paola-
dc.contributor.authorBarrales, Ramón R.-
dc.contributor.authorBraun, Sigurd-
dc.contributor.authorDaga, Rafael R.-
dc.date.accessioned2018-04-13T12:35:44Z-
dc.date.available2018-04-13T12:35:44Z-
dc.date.issued2017-
dc.identifierdoi: 10.1083/jcb.201612194-
dc.identifiere-issn: 1540-8140-
dc.identifierissn: 0021-9525-
dc.identifier.citationJournal of Cell Biology 216(11): 3591-3608 (2017)-
dc.identifier.urihttp://hdl.handle.net/10261/163626-
dc.description.abstractKinetochores (KTs) are large multiprotein complexes that constitute the interface between centromeric chromatin and the mitotic spindle during chromosome segregation. In spite of their essential role, little is known about how centromeres and KTs are assembled and how their precise stoichiometry is regulated. In this study, we show that the nuclear pore basket component Alm1 is required to maintain both the proteasome and its anchor, Cut8, at the nuclear envelope, which in turn regulates proteostasis of certain inner KT components. Consistently, alm1-deleted cells show increased levels of KT proteins, including CENP-CCnp3, spindle assembly checkpoint activation, and chromosome segregation defects. Our data demonstrate a novel function of the nucleoporin Alm1 in proteasome localization required for KT homeostasis.-
dc.description.sponsorshipThis work was supported by the Ministerio de Economía y Competitividad of the Spanish government (grant BFU2015-70604-P to R.R. Daga). P. Gallardo was supported by a grant from Universidad Pablo de Olavide (grant Beca Puente PP1-1402).-
dc.publisherRockefeller University Press-
dc.relationinfo:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/BFU2015-70604-P-
dc.relation.isversionofPublisher's version-
dc.rightsopenAccess-
dc.titleThe fission yeast nucleoporin Alm1 is required for proteasomal degradation of kinetochore components-
dc.typeartículo-
dc.identifier.doi10.1083/jcb.201612194-
dc.relation.publisherversionhttps://doi.org/10.1083/jcb.201612194-
dc.date.updated2018-04-13T12:35:44Z-
dc.description.versionPeer Reviewed-
dc.language.rfc3066eng-
dc.rights.licensehttps://creativecommons.org/licenses/by-nc-sa/4.0/-
dc.contributor.funderMinisterio de Economía y Competitividad (España)-
dc.contributor.funderUniversidad Pablo de Olavide-
dc.relation.csic-
dc.identifier.funderhttp://dx.doi.org/10.13039/501100003329es_ES
dc.identifier.pmid28974540-
dc.type.coarhttp://purl.org/coar/resource_type/c_6501es_ES
item.openairetypeartículo-
item.cerifentitytypePublications-
item.grantfulltextopen-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextWith Fulltext-
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