English   español  
Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/163626
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

The fission yeast nucleoporin Alm1 is required for proteasomal degradation of kinetochore components

AutorSalas-Pino, Silvia ; Gallardo, Paola; Barrales, Ramón R.; Braun, Sigurd; Daga, Rafael R.
Fecha de publicación2017
EditorRockefeller University Press
CitaciónJournal of Cell Biology 216(11): 3591-3608 (2017)
ResumenKinetochores (KTs) are large multiprotein complexes that constitute the interface between centromeric chromatin and the mitotic spindle during chromosome segregation. In spite of their essential role, little is known about how centromeres and KTs are assembled and how their precise stoichiometry is regulated. In this study, we show that the nuclear pore basket component Alm1 is required to maintain both the proteasome and its anchor, Cut8, at the nuclear envelope, which in turn regulates proteostasis of certain inner KT components. Consistently, alm1-deleted cells show increased levels of KT proteins, including CENP-CCnp3, spindle assembly checkpoint activation, and chromosome segregation defects. Our data demonstrate a novel function of the nucleoporin Alm1 in proteasome localization required for KT homeostasis.
Versión del editorhttps://doi.org/10.1083/jcb.201612194
Identificadoresdoi: 10.1083/jcb.201612194
e-issn: 1540-8140
issn: 0021-9525
Aparece en las colecciones: (CABD) Artículos
Ficheros en este ítem:
Fichero Descripción Tamaño Formato  
fissioncompo.pdf2,71 MBAdobe PDFVista previa
Mostrar el registro completo

Artículos relacionados:

NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.