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dc.contributor.authorAlbuixech-Crespo, Beatriz-
dc.contributor.authorBurguera, Demian-
dc.contributor.authorMaeso, Ignacio-
dc.contributor.authorMoreno-Bravo, Juan Antonio-
dc.contributor.authorSánchez-Arrones, Luisa-
dc.contributor.authorBovolenta, Paola-
dc.contributor.authorGarcia-Fernàndez, Jordi-
dc.contributor.authorPuelles, Eduardo-
dc.contributor.authorIrimia, Manuel-
dc.contributor.authorFerrán, José Luis-
dc.date.accessioned2018-04-13T07:48:55Z-
dc.date.available2018-04-13T07:48:55Z-
dc.date.issued2017-
dc.identifierdoi: 10.1371/journal.pbio.2001573-
dc.identifiere-issn: 1545-7885-
dc.identifierissn: 1544-9173-
dc.identifier.citationPLoS Biology 15(4): e2001573 (2017)-
dc.identifier.urihttp://hdl.handle.net/10261/163593-
dc.descriptionet al.-
dc.description.abstractAll vertebrate brains develop following a common Bauplan defined by anteroposterior (AP) and dorsoventral (DV) subdivisions, characterized by largely conserved differential expression of gene markers. However, it is still unclear how this Bauplan originated during evolution. We studied the relative expression of 48 genes with key roles in vertebrate neural patterning in a representative amphioxus embryonic stage. Unlike nonchordates, amphioxus develops its central nervous system (CNS) from a neural plate that is homologous to that of vertebrates, allowing direct topological comparisons. The resulting genoarchitectonic model revealed that the amphioxus incipient neural tube is unexpectedly complex, consisting of several AP and DV molecular partitions. Strikingly, comparison with vertebrates indicates that the vertebrate thalamus, pretectum, and midbrain domains jointly correspond to a single amphioxus region, which we termed Di-Mesencephalic primordium (DiMes). This suggests that these domains have a common developmental and evolutionary origin, as supported by functional experiments manipulating secondary organizers in zebrafish and mice.-
dc.description.sponsorshipSpanish Ministry of Economy and Competitiveness and European FEDER funds (grant number BFU2014-57516-P). To Luis Puelles and Jose Luis Ferran. European Research Council (grant number ERC-StG-LS2-637591). To Manuel Irimia. Spanish Ministry of Economy and Competitiveness (grant number SEV-2012-0208). Centro de Excelencia Severo Ochoa (to CRG, Manuel Irimia). Spanish Ministry of Economy and Competitiveness (grant number BFU2014-58908-P). To Jordi GarciaFernadez. Seneca Foundation, Comunidad de Murcia (grant number 19904/ GERM/15). To Luis Puelles. Generalitat de Catalunya (grant number). ICREA Academia Prize to Jordi GarciaFernandez. Spanish Ministry of Economy and Competitiveness (grant number BFU2013-43213-P). To Paola Bovolenta. Spanish Ministry of Economy and Competitiveness (grant number BFU2014-55076-P). To Manuel Irimia. Including an FPI PhD fellowship to Laura Lopez-Blanch. Marine Alliance for Science and Technology Scotland (MASTS) (grant number). To Ildiko Somorjai.-
dc.publisherPublic Library of Science-
dc.relationMINECO/ICTI2013-2016/BFU2014-55076-P-
dc.relationMINECO/ICTI2013-2016/BFU2014-57516-P-
dc.relationinfo:eu-repo/grantAgreement/EC/H2020/637591-
dc.relationMINECO/ICTI2013-2016/BFU2014-58908-P-
dc.relationMINECO/ICTI2013-2016/BFU2013-43213-P-
dc.relation.isversionofPublisher's version-
dc.rightsopenAccess-
dc.titleMolecular regionalization of the developing amphioxus neural tube challenges major partitions of the vertebrate brain-
dc.typeartículo-
dc.relation.publisherversionhttps://doi.org/10.1371/journal.pbio.2001573-
dc.date.updated2018-04-13T07:48:55Z-
dc.description.versionPeer Reviewed-
dc.language.rfc3066eng-
dc.rights.licensehttp://creativecommons.org/licenses/by/4.0/-
dc.contributor.funderMarine Alliance for Science and Technology for Scotland-
dc.contributor.funderEuropean Commission-
dc.contributor.funderMinisterio de Economía y Competitividad (España)-
dc.contributor.funderGeneralitat de Catalunya-
dc.contributor.funderEuropean Research Council-
dc.contributor.funderFundación Séneca-
dc.contributor.funderGobierno de la Región de Murcia-
dc.relation.csic-
dc.identifier.funderhttp://dx.doi.org/10.13039/501100003329es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100002809es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100000781es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/100007801es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100000780es_ES
dc.identifier.pmid28422959-
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