English   español  
Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/163593
Título

Molecular regionalization of the developing amphioxus neural tube challenges major partitions of the vertebrate brain

AutorAlbuixech-Crespo, Beatriz; Burguera, Demian; Maeso, Ignacio; Moreno-Bravo, Juan Antonio; Sánchez-Arrones, Luisa ; Bovolenta, Paola ; García-Fernández, Jordi; Puelles, Eduardo; Irimia, Manuel; Ferrán, José Luis
Fecha de publicación2017
EditorPublic Library of Science
CitaciónPLoS Biology 15(4): e2001573 (2017)
ResumenAll vertebrate brains develop following a common Bauplan defined by anteroposterior (AP) and dorsoventral (DV) subdivisions, characterized by largely conserved differential expression of gene markers. However, it is still unclear how this Bauplan originated during evolution. We studied the relative expression of 48 genes with key roles in vertebrate neural patterning in a representative amphioxus embryonic stage. Unlike nonchordates, amphioxus develops its central nervous system (CNS) from a neural plate that is homologous to that of vertebrates, allowing direct topological comparisons. The resulting genoarchitectonic model revealed that the amphioxus incipient neural tube is unexpectedly complex, consisting of several AP and DV molecular partitions. Strikingly, comparison with vertebrates indicates that the vertebrate thalamus, pretectum, and midbrain domains jointly correspond to a single amphioxus region, which we termed Di-Mesencephalic primordium (DiMes). This suggests that these domains have a common developmental and evolutionary origin, as supported by functional experiments manipulating secondary organizers in zebrafish and mice.
Descripciónet al.
Versión del editorhttps://doi.org/10.1371/journal.pbio.2001573
URIhttp://hdl.handle.net/10261/163593
Identificadoresdoi: 10.1371/journal.pbio.2001573
e-issn: 1545-7885
issn: 1544-9173
Aparece en las colecciones: (IN) Artículos
(CBM) Artículos
(CABD) Artículos
Ficheros en este ítem:
Fichero Descripción Tamaño Formato  
moleculabrain.pdf11,85 MBAdobe PDFVista previa
Visualizar/Abrir
Mostrar el registro completo
 

Artículos relacionados:


NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.