English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/163537
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

Title

Potyvirus virion structure shows conserved protein fold and RNA binding site in ssRNA viruses

AuthorsZamora, Miguel; Méndez-López, Eduardo; Agirrezabala, Xabier; Cuesta, Rebeca; Lavín, José L.; Sánchez-Pina, M. Amelia ; Aranda, Miguel A. ; Valle, Mikel
Issue Date1-Sep-2017
PublisherAmerican Association for the Advancement of Science
CitationScience Advances 3(9): eaao2182 (2017)
AbstractPotyviruses constitute the second largest genus of plant viruses and cause important economic losses in a large variety of crops; however, the atomic structure of their particles remains unknown. Infective potyvirus virions are long flexuous filaments where coat protein (CP) subunits assemble in helical mode bound to a monopartite positive-sense single-stranded RNA [(+)ssRNA] genome. We present the cryo-electron microscopy (cryoEM) structure of the potyvirus watermelon mosaic virus at a resolution of 4.0 Å. The atomic model shows a conserved fold for the CPs of flexible filamentous plant viruses, including a universally conserved RNA binding pocket, which is a potential target for antiviral compounds. This conserved fold of the CP is widely distributed in eukaryotic viruses and is also shared by nucleoproteins of enveloped viruses with segmented (−)ssRNA (negative-sense ssRNA) genomes, including influenza viruses.
Publisher version (URL)http://dx.doi.org/10.1126/sciadv.aao2182
URIhttp://hdl.handle.net/10261/163537
DOI10.1126/sciadv.aao2182
E-ISSN2375-2548
Appears in Collections:(CEBAS) Artículos
Files in This Item:
File Description SizeFormat 
ssRNA_viruses_Zamora.pdf8,19 MBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.