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Título

Coordinated morphogenetic mechanisms shape the vertebrate eye

AutorMartínez-Morales, Juan Ramón CSIC ORCID; Cavodeassi, Florencia CSIC ORCID; Bovolenta, Paola CSIC ORCID
Palabras claveEye development
Cell movement
Morphogenesis
Patterning
Retina pigment epithelim
Vertebrates
Cell shape
Fecha de publicación2017
EditorFrontiers Media
CitaciónFrontiers in Neuroscience 11: 721 (2017)
ResumenThe molecular bases of vertebrate eye formation have been extensively investigated during the past 20 years. This has resulted in the definition of the backbone of the gene regulatory networks controlling the different steps of eye development and has further highlighted a substantial conservation of these networks among vertebrates. Yet, the precise morphogenetic events allowing the formation of the optic cup from a small group of cells within the anterior neural plate are still poorly understood. It is also unclear if the morphogenetic events leading to eyes of very similar shape are indeed comparable among all vertebrates or if there are any species-specific peculiarities. Improved imaging techniques have enabled to follow how the eye forms in living embryos of a few vertebrate models, whereas the development of organoid cultures has provided fascinating tools to recapitulate tissue morphogenesis of other less accessible species. Here, we will discuss what these advances have taught us about eye morphogenesis, underscoring possible similarities and differences among vertebrates. We will also discuss the contribution of cell shape changes to this process and how morphogenetic and patterning mechanisms integrate to assemble the final architecture of the eye.
Versión del editorhttps://doi.org/10.3389/fnins.2017.00721
URIhttp://hdl.handle.net/10261/163478
DOI10.3389/fnins.2017.00721
Identificadoresdoi: 10.3389/fnins.2017.00721
e-issn: 1662-453X
issn: 1662-4548
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