Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/163444
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Desbats, María Andrea | - |
dc.contributor.author | Doimo, Mara | - |
dc.contributor.author | Navas, Plácido | - |
dc.contributor.author | Salviati, Leonardo | - |
dc.contributor.author | Trevisson, Eva | - |
dc.date.accessioned | 2018-04-11T07:07:47Z | - |
dc.date.available | 2018-04-11T07:07:47Z | - |
dc.date.issued | 2016 | - |
dc.identifier | doi: 10.1093/hmg/ddw257 | - |
dc.identifier | e-issn: 1460-2083 | - |
dc.identifier | issn: 0964-6906 | - |
dc.identifier.citation | Human Molecular Genetics 25(19): 4256-4265 (2016) | - |
dc.identifier.uri | http://hdl.handle.net/10261/163444 | - |
dc.description | et al. | - |
dc.description.abstract | COQ2 (p-hydroxybenzoate polyprenyl transferase) encodes the enzyme required for the second step of the final reaction sequence of Coenzyme Q10 (CoQ) biosynthesis. Its mutations represent a frequent cause of primary CoQ deficiency and have been associated with the widest clinical spectrum, ranging from fatal neonatal multisystemic disease to late-onset encephalopathy. However, the reasons of this variability are still unknown. We have characterized the structure of human COQ2, defined its subcellular localization and developed a yeast model to validate all the mutant alleles reported so far. Our findings show that the main functional transcript of COQ2 is shorter than what was previously reported and that its protein product localizes to mitochondria with the C-terminus facing the intermembrane space. Complementation experiments in yeast showed that the residual activity of the mutant proteins correlates with the clinical phenotypes observed in patients. We defined the structure of COQ2 with relevant implications for mutation screening in patients and demonstrated that, contrary to other COQ gene defects such as ADCK3, there is a correlation between COQ2 genotype and patient's phenotype. | - |
dc.description.sponsorship | This work was supported by the Italian Ministry of Health [GR2009-1578914 to E.T.]; University of Padova [CPDA140508/14 to E.T.]; Telethon Italy [GGP13222, GGP14187 to L.S.] and by Fondazione CARIPARO [to L.S.]. | - |
dc.publisher | Oxford University Press | - |
dc.rights | closedAccess | - |
dc.title | The COQ2 genotype predicts the severity of Coenzyme Q10 deficiency | - |
dc.type | artículo | - |
dc.identifier.doi | 10.1093/hmg/ddw257 | - |
dc.date.updated | 2018-04-11T07:07:47Z | - |
dc.description.version | Peer Reviewed | - |
dc.language.rfc3066 | eng | - |
dc.contributor.funder | Ministero della Salute | - |
dc.contributor.funder | Università degli Studi di Padova | - |
dc.contributor.funder | Fondazione Cariplo | - |
dc.contributor.funder | Fondazione Telethon | - |
dc.relation.csic | Sí | - |
dc.identifier.funder | http://dx.doi.org/10.13039/501100003500 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100002803 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100002426 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100003196 | es_ES |
dc.identifier.pmid | 27493029 | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.fulltext | No Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | none | - |
item.openairetype | artículo | - |
Aparece en las colecciones: | (CABD) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
accesoRestringido.pdf | 15,38 kB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
PubMed Central
Citations
29
checked on 10-abr-2024
SCOPUSTM
Citations
48
checked on 17-abr-2024
WEB OF SCIENCETM
Citations
39
checked on 27-feb-2024
Page view(s)
213
checked on 22-abr-2024
Download(s)
26
checked on 22-abr-2024
Google ScholarTM
Check
Altmetric
Altmetric
Artículos relacionados:
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.