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http://hdl.handle.net/10261/163349
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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Street, Steven T. G. | es_ES |
dc.contributor.author | Chin, Donovan N. | es_ES |
dc.contributor.author | Hollingworth, Gregory J. | es_ES |
dc.contributor.author | Berry, Monica | es_ES |
dc.contributor.author | Morales, Juan C. | es_ES |
dc.contributor.author | Galán, M. Carmen | es_ES |
dc.date.accessioned | 2018-04-09T12:14:10Z | - |
dc.date.available | 2018-04-09T12:14:10Z | - |
dc.date.issued | 2017-03-30 | - |
dc.identifier.citation | Chemistry - a European Journal | es_ES |
dc.identifier.issn | 0947-6539 | - |
dc.identifier.uri | http://hdl.handle.net/10261/163349 | - |
dc.description.abstract | Selective G‐quadruplex ligands offer great promise for the development of anti‐cancer therapies. A novel series of divalent cationic naphthalene diimide ligands that selectively bind to the hybrid form of the human telomeric G‐quadruplex in K+ buffer are described herein. We demonstrate that an imidazolium‐bearing mannoside‐conjugate is the most selective ligand to date for this quadruplex against several other quadruplex and duplex structures. We also show that a similarly selective methylpiperazine‐bearing ligand was more toxic to HeLa cancer cells than doxorubicin, whilst exhibiting three times less toxicity towards fetal lung fibroblasts WI‐38. | es_ES |
dc.description.sponsorship | S.T.G.S.thanksDr.A.Izaac(Novartis)for support withITC, Dr.A.Bailey(Bristol)for use of qPCRand BrisSynBIo(BB/L01386X/1)for use of the NanoDrop UV/Vis spectrophotometer and PlateReader, Dr.A.Leardand the WolfsonBioimagingFacility(BB/L014181/1)for supportwith ConfocalMicroscopy andEPSRCEP/G036764/1for aPhD studentship.M.C.G.thanksthe EPSRCEP/J002542/1and ERC-COG648239 for funding. J.C.M.thanksMinisterio de EconomíayCompetitividad(CTQ2012-35360 andCTQ2015-64275-P | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | John Wiley & Sons | es_ES |
dc.relation.isversionof | Publisher's version | es_ES |
dc.rights | openAccess | es_ES |
dc.subject | Antitumour agents | es_ES |
dc.subject | Carbohydrates | es_ES |
dc.subject | Drug design | es_ES |
dc.subject | G-quadruplexes | es_ES |
dc.subject | Molecular recognition | es_ES |
dc.title | Divalent Naphthalene Diimide Ligands Display High Selectivity for the Human Telomeric G‐quadruplex in K+ Buffer | es_ES |
dc.type | artículo | es_ES |
dc.identifier.doi | 10.1002/chem.201700140 | - |
dc.description.peerreviewed | Peer reviewed | es_ES |
dc.relation.publisherversion | https://onlinelibrary.wiley.com/doi/abs/10.1002/chem.201700140 | es_ES |
dc.identifier.e-issn | 1521-3765 | - |
dc.rights.license | https://creativecommons.org/licenses/by/4.0/ | es_ES |
dc.relation.csic | Sí | es_ES |
oprm.item.hasRevision | no ko 0 false | * |
dc.identifier.pmid | 28257554 | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | With Fulltext | - |
item.cerifentitytype | Publications | - |
item.openairetype | artículo | - |
item.languageiso639-1 | en | - |
item.grantfulltext | open | - |
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ChemEurJ2017_Street_et_al.pdf | 1,26 MB | Adobe PDF | Visualizar/Abrir |
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