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Title

Identification and characterization of the dermal Panniculus carnosus muscle stem cells

AuthorsNaldaiz-Gastesi, Neia; López-Mayorga, Macarena CSIC; Herrero, Diego; Bernad, Antonio; García-Verdugo, José M.; Carvajal, Jaime J. CSIC ORCID; López de Munain, Adolfo; García-Parra, Patricia; Izeta, Ander
Issue Date2016
PublisherElsevier
Cell Press
CitationStem Cell Reports 7(3): 411-424 (2016)
AbstractThe dermal Panniculus carnosus (PC) muscle is important for wound contraction in lower mammals and represents an interesting model of muscle regeneration due to its high cell turnover. The resident satellite cells (the bona fide muscle stem cells) remain poorly characterized. Here we analyzed PC satellite cells with regard to developmental origin and purported function. Lineage tracing shows that they originate in Myf5, Pax3/Pax7 cell populations. Skin and muscle wounding increased PC myofiber turnover, with the satellite cell progeny being involved in muscle regeneration but with no detectable contribution to the wound-bed myofibroblasts. Since hematopoietic stem cells fuse to PC myofibers in the absence of injury, we also studied the contribution of bone marrow-derived cells to the PC satellite cell compartment, demonstrating that cells of donor origin are capable of repopulating the PC muscle stem cell niche after irradiation and bone marrow transplantation but may not fully acquire the relevant myogenic commitment.
Descriptionet al.
Publisher version (URL)https://doi.org/10.1016/j.stemcr.2016.08.002
URIhttp://hdl.handle.net/10261/163326
DOI10.1016/j.stemcr.2016.08.002
Identifiersdoi: 10.1016/j.stemcr.2016.08.002
e-issn: 2213-6711
Appears in Collections:(CNB) Artículos
(CABD) Artículos

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