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Título

Favorable genomic environments for cis-regulatory evolution: A novel theoretical framework

AutorMaeso, Ignacio; Tena, Juan J.
Palabras claveTransposable element
Cis-regulation
Enhancer evolution
Enhancer overprinting
Transcription factor binding site (TFBS)
Chromatin environment
Fecha de publicación2016
EditorElsevier
CitaciónSeminars in Cell and Developmental Biology 57: 2-10 (2016)
ResumenCis-regulatory changes are arguably the primary evolutionary source of animal morphological diversity. With the recent explosion of genome-wide comparisons of the cis-regulatory content in different animal species is now possible to infer general principles underlying enhancer evolution. However, these studies have also revealed numerous discrepancies and paradoxes, suggesting that the mechanistic causes and modes of cis-regulatory evolution are still not well understood and are probably much more complex than generally appreciated. Here, we argue that the mutational mechanisms and genomic regions generating new regulatory activities must comply with the constraints imposed by the molecular properties of cis-regulatory elements (CREs) and the organizational features of long-range chromatin interactions. Accordingly, we propose a new integrative evolutionary framework for cis-regulatory evolution based on two major premises for the origin of novel enhancer activity: (i) an accessible chromatin environment and (ii) compatibility with the 3D structure and interactions of pre-existing CREs. Mechanisms and DNA sequences not fulfilling these premises, will be less likely to have a measurable impact on gene expression and as such, will have a minor contribution to the evolution of gene regulation. Finally, we discuss current comparative cis-regulatory data under the light of this new evolutionary model, and propose that the two most prominent mechanisms for the evolution of cis-regulatory changes are the overprinting of ancestral CREs and the exaptation of transposable elements.
Versión del editorhttps://doi.org/10.1016/j.semcdb.2015.12.003
URIhttp://hdl.handle.net/10261/163302
Identificadoresdoi: 10.1016/j.semcdb.2015.12.003
e-issn: 1096-3634
issn: 1084-9521
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