Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/163302
Share/Export:
logo share SHARE logo core CORE BASE
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE
Title

Favorable genomic environments for cis-regulatory evolution: A novel theoretical framework

AuthorsMaeso, Ignacio; Tena, Juan J. CSIC ORCID
KeywordsTransposable element
Cis-regulation
Enhancer evolution
Enhancer overprinting
Transcription factor binding site (TFBS)
Chromatin environment
Issue Date2016
PublisherElsevier
CitationSeminars in Cell and Developmental Biology 57: 2-10 (2016)
AbstractCis-regulatory changes are arguably the primary evolutionary source of animal morphological diversity. With the recent explosion of genome-wide comparisons of the cis-regulatory content in different animal species is now possible to infer general principles underlying enhancer evolution. However, these studies have also revealed numerous discrepancies and paradoxes, suggesting that the mechanistic causes and modes of cis-regulatory evolution are still not well understood and are probably much more complex than generally appreciated. Here, we argue that the mutational mechanisms and genomic regions generating new regulatory activities must comply with the constraints imposed by the molecular properties of cis-regulatory elements (CREs) and the organizational features of long-range chromatin interactions. Accordingly, we propose a new integrative evolutionary framework for cis-regulatory evolution based on two major premises for the origin of novel enhancer activity: (i) an accessible chromatin environment and (ii) compatibility with the 3D structure and interactions of pre-existing CREs. Mechanisms and DNA sequences not fulfilling these premises, will be less likely to have a measurable impact on gene expression and as such, will have a minor contribution to the evolution of gene regulation. Finally, we discuss current comparative cis-regulatory data under the light of this new evolutionary model, and propose that the two most prominent mechanisms for the evolution of cis-regulatory changes are the overprinting of ancestral CREs and the exaptation of transposable elements.
Publisher version (URL)https://doi.org/10.1016/j.semcdb.2015.12.003
URIhttp://hdl.handle.net/10261/163302
DOI10.1016/j.semcdb.2015.12.003
Identifiersdoi: 10.1016/j.semcdb.2015.12.003
e-issn: 1096-3634
issn: 1084-9521
Appears in Collections:(CABD) Artículos

Files in This Item:
File Description SizeFormat
favorableframework.pdf642,94 kBAdobe PDFThumbnail
View/Open
Show full item record
Review this work

PubMed Central
Citations

9
checked on Dec 6, 2021

SCOPUSTM   
Citations

13
checked on Nov 30, 2021

WEB OF SCIENCETM
Citations

12
checked on Dec 1, 2021

Google ScholarTM

Check

Altmetric

Dimensions


Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.