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dc.contributor.author | Carro, Juan | - |
dc.contributor.author | Fernández-Fueyo, Elena | - |
dc.contributor.author | Fernández-Alonso, M. Carmen | - |
dc.contributor.author | Cañada, F. Javier | - |
dc.contributor.author | Ullrich, René | - |
dc.contributor.author | Hofrichter, Martin | - |
dc.contributor.author | Alcalde Galeote, Miguel | - |
dc.contributor.author | Ferreira, Patricia | - |
dc.contributor.author | Martínez, Ángel T. | - |
dc.date.accessioned | 2018-04-08T03:30:29Z | - |
dc.date.available | 2018-04-08T03:30:29Z | - |
dc.date.issued | 2018-04-02 | - |
dc.identifier.citation | Biotechnology for Biofuels 11(1): 86 (2018) | - |
dc.identifier.uri | http://hdl.handle.net/10261/163280 | - |
dc.description.abstract | Abstract Background 2,5-Furandicarboxylic acid is a renewable building block for the production of polyfurandicarboxylates, which are biodegradable polyesters expected to substitute their classical counterparts derived from fossil resources. It may be produced from bio-based 5-hydroxymethylfurfural or 5-methoxymethylfurfural, both obtained by the acidic dehydration of biomass-derived fructose. 5-Methoxymethylfurfural, which is produced in the presence of methanol, generates less by-products and exhibits better storage stability than 5-hydroxymethylfurfural being, therefore, the industrial substrate of choice. Results In this work, an enzymatic cascade involving three fungal oxidoreductases has been developed for the production of 2,5-furandicarboxylic acid from 5-methoxymethylfurfural. Aryl-alcohol oxidase and unspecific peroxygenase act on 5-methoxymethylfurfural and its partially oxidized derivatives yielding 2,5-furandicarboxylic acid, as well as methanol as a by-product. Methanol oxidase takes advantage of the methanol released for in situ producing H2O2 that, along with that produced by aryl-alcohol oxidase, fuels the peroxygenase reactions. In this way, the enzymatic cascade proceeds independently, with the only input of atmospheric O2, to attain a 70% conversion of initial 5-methoxymethylfurfural. The addition of some exogenous methanol to the reaction further improves the yield to attain an almost complete conversion of 5-methoxymethylfurfural into 2,5-furandicarboxylic acid. Conclusions The synergistic action of aryl-alcohol oxidase and unspecific peroxygenase in the presence of 5-methoxymethylfurfural and O2 is sufficient for the production of 2,5-furandicarboxylic acid. The addition of methanol oxidase to the enzymatic cascade increases the 2,5-furandicarboxylic acid yields by oxidizing a reaction by-product to fuel the peroxygenase reactions. | - |
dc.description.sponsorship | This work has been funded by the H2020 BBI-JU (http://www.bbi-europe.eu) project EnzOx2 (H2020-BBI-PPP-2015-2-720297) together with the INDOX EU project (FP7-KBBE-2013-7-613549) and the NOESIS (BIO2014-56388-R) and GENOBIOREF (BIO2017-86559-R) projects of the Spanish Ministry of Economy, Industry and Competitiveness, co-fnanced by FEDER funds. | - |
dc.description.sponsorship | We acknowledge support by the CSIC Open Access Publication Initiative through its Unit of Information Resources for Research (URICI). | - |
dc.publisher | BioMed Central | - |
dc.relation | info:eu-repo/grantAgreement/EC/H2020/720297 | - |
dc.relation | info:eu-repo/grantAgreement/EC/FP7/613549 | - |
dc.relation | info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/BIO2014-56388-R | - |
dc.relation | info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/BIO2017-86559-R | - |
dc.relation.isversionof | Publisher's version | - |
dc.rights | openAccess | - |
dc.title | Self-sustained enzymatic cascade for the production of 2,5-furandicarboxylic acid from 5-methoxymethylfurfural | - |
dc.type | artículo | - |
dc.identifier.doi | 10.1186/s13068-018-1091-2 | - |
dc.relation.publisherversion | https://doi.org/10.1186/s13068-018-1091-2 | - |
dc.date.updated | 2018-04-08T03:30:29Z | - |
dc.language.rfc3066 | en | - |
dc.rights.holder | The Author(s) | - |
dc.rights.license | http://creativecommons.org/licenses/by/4.0/ | - |
dc.contributor.funder | Ministerio de Economía, Industria y Competitividad (España) | - |
dc.contributor.funder | European Commission | - |
dc.contributor.funder | CSIC - Unidad de Recursos de Información Científica para la Investigación (URICI) | - |
dc.relation.csic | Sí | - |
dc.identifier.funder | http://dx.doi.org/10.13039/501100000780 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100010198 | es_ES |
dc.identifier.pmid | 29619082 | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairetype | artículo | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | open | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | With Fulltext | - |
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