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dc.contributor.authorCarro, Juan-
dc.contributor.authorFernández-Fueyo, Elena-
dc.contributor.authorFernández-Alonso, M. Carmen-
dc.contributor.authorCañada, F. Javier-
dc.contributor.authorUllrich, René-
dc.contributor.authorHofrichter, Martin-
dc.contributor.authorAlcalde Galeote, Miguel-
dc.contributor.authorFerreira, Patricia-
dc.contributor.authorMartínez, Ángel T.-
dc.date.accessioned2018-04-08T03:30:29Z-
dc.date.available2018-04-08T03:30:29Z-
dc.date.issued2018-04-02-
dc.identifier.citationBiotechnology for Biofuels 11(1): 86 (2018)-
dc.identifier.urihttp://hdl.handle.net/10261/163280-
dc.description.abstractAbstract Background 2,5-Furandicarboxylic acid is a renewable building block for the production of polyfurandicarboxylates, which are biodegradable polyesters expected to substitute their classical counterparts derived from fossil resources. It may be produced from bio-based 5-hydroxymethylfurfural or 5-methoxymethylfurfural, both obtained by the acidic dehydration of biomass-derived fructose. 5-Methoxymethylfurfural, which is produced in the presence of methanol, generates less by-products and exhibits better storage stability than 5-hydroxymethylfurfural being, therefore, the industrial substrate of choice. Results In this work, an enzymatic cascade involving three fungal oxidoreductases has been developed for the production of 2,5-furandicarboxylic acid from 5-methoxymethylfurfural. Aryl-alcohol oxidase and unspecific peroxygenase act on 5-methoxymethylfurfural and its partially oxidized derivatives yielding 2,5-furandicarboxylic acid, as well as methanol as a by-product. Methanol oxidase takes advantage of the methanol released for in situ producing H2O2 that, along with that produced by aryl-alcohol oxidase, fuels the peroxygenase reactions. In this way, the enzymatic cascade proceeds independently, with the only input of atmospheric O2, to attain a 70% conversion of initial 5-methoxymethylfurfural. The addition of some exogenous methanol to the reaction further improves the yield to attain an almost complete conversion of 5-methoxymethylfurfural into 2,5-furandicarboxylic acid. Conclusions The synergistic action of aryl-alcohol oxidase and unspecific peroxygenase in the presence of 5-methoxymethylfurfural and O2 is sufficient for the production of 2,5-furandicarboxylic acid. The addition of methanol oxidase to the enzymatic cascade increases the 2,5-furandicarboxylic acid yields by oxidizing a reaction by-product to fuel the peroxygenase reactions.-
dc.description.sponsorshipThis work has been funded by the H2020 BBI-JU (http://www.bbi-europe.eu) project EnzOx2 (H2020-BBI-PPP-2015-2-720297) together with the INDOX EU project (FP7-KBBE-2013-7-613549) and the NOESIS (BIO2014-56388-R) and GENOBIOREF (BIO2017-86559-R) projects of the Spanish Ministry of Economy, Industry and Competitiveness, co-fnanced by FEDER funds.-
dc.description.sponsorshipWe acknowledge support by the CSIC Open Access Publication Initiative through its Unit of Information Resources for Research (URICI).-
dc.publisherBioMed Central-
dc.relationinfo:eu-repo/grantAgreement/EC/H2020/720297-
dc.relationinfo:eu-repo/grantAgreement/EC/FP7/613549-
dc.relationinfo:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/BIO2014-56388-R-
dc.relationinfo:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/BIO2017-86559-R-
dc.relation.isversionofPublisher's version-
dc.rightsopenAccess-
dc.titleSelf-sustained enzymatic cascade for the production of 2,5-furandicarboxylic acid from 5-methoxymethylfurfural-
dc.typeartículo-
dc.identifier.doi10.1186/s13068-018-1091-2-
dc.relation.publisherversionhttps://doi.org/10.1186/s13068-018-1091-2-
dc.date.updated2018-04-08T03:30:29Z-
dc.language.rfc3066en-
dc.rights.holderThe Author(s)-
dc.rights.licensehttp://creativecommons.org/licenses/by/4.0/-
dc.contributor.funderMinisterio de Economía, Industria y Competitividad (España)-
dc.contributor.funderEuropean Commission-
dc.contributor.funderCSIC - Unidad de Recursos de Información Científica para la Investigación (URICI)-
dc.relation.csic-
dc.identifier.funderhttp://dx.doi.org/10.13039/501100000780es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100010198es_ES
dc.identifier.pmid29619082-
dc.type.coarhttp://purl.org/coar/resource_type/c_6501es_ES
item.openairetypeartículo-
item.cerifentitytypePublications-
item.grantfulltextopen-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextWith Fulltext-
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