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Editorial: Role of stem cells in skeletal muscle development, regeneration, repair, aging and disease

AutorMuñoz-Cánoves, Pura; Carvajal, Jaime J. ; López de Munain, Adolfo; Izeta, Ander
Palabras claveSatellite cells
Muscle dystrophies
Signaling pathways
Muscle atrophy
Fecha de publicación2016
EditorFrontiers Media
CitaciónFrontiers in Aging Neuroscience 8: 95 (2016)
ResumenSkeletal muscle is a highly dynamic and plastic tissue, able to modify its intrinsic size or strength following electric impulse, mechanical loading, or diet. Several muscular dystrophic disorders have been characterized but the development of therapies, although promising, is still at an early phase. Muscle dysfunction is not restricted to dystrophic patients; during aging, there is a gradual loss of muscle function that results in a significant negative impact on the individual's health, increasing fall and lesion risks, loss of mobility and independence, and associated elevation of morbidity and mortality. This loss of muscle has an estimated prevalence between 5 and 13% among 60–70 year old individuals, increasing to 11–50% in those over the age of 80 (Morley, 2008). According to the WHO, the expected number of individuals over 65 years old by the year 2050 will be around 1.5 billion (WHO, 2015); by extrapolation, this suggests that over 150 million patients will suffer from muscle wasting disorders associated with aging.
Versión del editorhttps://doi.org/10.3389/fnagi.2016.00095
Identificadoresdoi: 10.3389/fnagi.2016.00095
e-issn: 1663-4365
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