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Title

Editorial: Role of stem cells in skeletal muscle development, regeneration, repair, aging and disease

AuthorsMuñoz-Cánoves, Pura; Carvajal, Jaime J. CSIC ORCID; López de Munain, Adolfo; Izeta, Ander
KeywordsSatellite cells
Pericytes
Centenarians
Myogenesis
Muscle dystrophies
Rejuvenation
Signaling pathways
Muscle atrophy
Issue Date2016
PublisherFrontiers Media
CitationFrontiers in Aging Neuroscience 8: 95 (2016)
AbstractSkeletal muscle is a highly dynamic and plastic tissue, able to modify its intrinsic size or strength following electric impulse, mechanical loading, or diet. Several muscular dystrophic disorders have been characterized but the development of therapies, although promising, is still at an early phase. Muscle dysfunction is not restricted to dystrophic patients; during aging, there is a gradual loss of muscle function that results in a significant negative impact on the individual's health, increasing fall and lesion risks, loss of mobility and independence, and associated elevation of morbidity and mortality. This loss of muscle has an estimated prevalence between 5 and 13% among 60–70 year old individuals, increasing to 11–50% in those over the age of 80 (Morley, 2008). According to the WHO, the expected number of individuals over 65 years old by the year 2050 will be around 1.5 billion (WHO, 2015); by extrapolation, this suggests that over 150 million patients will suffer from muscle wasting disorders associated with aging.
Publisher version (URL)https://doi.org/10.3389/fnagi.2016.00095
URIhttp://hdl.handle.net/10261/163270
DOI10.3389/fnagi.2016.00095
Identifiersdoi: 10.3389/fnagi.2016.00095
e-issn: 1663-4365
Appears in Collections:(CABD) Artículos

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