Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/163248
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | dachshund potentiates Hedgehog signaling during Drosophila retinogenesis |
Autor: | Bras-Pereira, Catarina CSIC ORCID; Potier, Delphine; Jacobs, Jelle; Aerts, Stein; Casares, Fernando CSIC ORCID; Janody, Florence | Fecha de publicación: | 2016 | Editor: | Public Library of Science | Citación: | PLoS Genetics 12(7): e1006204 (2016) | Resumen: | Proper organ patterning depends on a tight coordination between cell proliferation and differentiation. The patterning of Drosophila retina occurs both very fast and with high precision. This process is driven by the dynamic changes in signaling activity of the conserved Hedgehog (Hh) pathway, which coordinates cell fate determination, cell cycle and tissue morphogenesis. Here we show that during Drosophila retinogenesis, the retinal determination gene dachshund (dac) is not only a target of the Hh signaling pathway, but is also a modulator of its activity. Using developmental genetics techniques, we demonstrate that dac enhances Hh signaling by promoting the accumulation of the Gli transcription factor Cubitus interruptus (Ci) parallel to or downstream of fused. In the absence of dac, all Hh-mediated events associated to the morphogenetic furrow are delayed. One of the consequences is that, posterior to the furrow, dac- cells cannot activate a Roadkill-Cullin3 negative feedback loop that attenuates Hh signaling and which is necessary for retinal cells to continue normal differentiation. Therefore, dac is part of an essential positive feedback loop in the Hh pathway, guaranteeing the speed and the accuracy of Drosophila retinogenesis. | Versión del editor: | https://doi.org/10.1371/journal.pgen.1006204 | URI: | http://hdl.handle.net/10261/163248 | DOI: | 10.1371/journal.pgen.1006204 | Identificadores: | doi: 10.1371/journal.pgen.1006204 e-issn: 1553-7404 issn: 1553-7390 |
Aparece en las colecciones: | (CABD) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
dachshundreti.PDF | 27,65 MB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
PubMed Central
Citations
8
checked on 29-mar-2024
SCOPUSTM
Citations
11
checked on 15-abr-2024
WEB OF SCIENCETM
Citations
11
checked on 25-feb-2024
Page view(s)
244
checked on 22-abr-2024
Download(s)
258
checked on 22-abr-2024