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Título: | Interactome and Gene Ontology provide congruent yet subtly different views of a eukaryotic cell |
Autor: | Marco, Antonio; Marín, Ignacio CSIC ORCID | Fecha de publicación: | 15-jul-2009 | Editor: | BioMed Central | Citación: | BMC Systems Biology 2009, 3:69 | Resumen: | BACKGROUND: The characterization of the global functional structure of a cell is a major goal in bioinformatics and systems biology. Gene Ontology (GO) and the protein-protein interaction network offer alternative views of that structure. RESULTS: This study presents a comparison of the global structures of the Gene Ontology and the interactome of Saccharomyces cerevisiae. Sensitive, unsupervised methods of clustering applied to a large fraction of the proteome led to establish a GO-interactome correlation value of +0.47 for a general dataset that contains both high and low-confidence interactions and +0.58 for a smaller, high-confidence dataset. CONCLUSION: The structures of the yeast cell deduced from GO and interactome are substantially congruent. However, some significant differences were also detected, which may contribute to a better understanding of cell function and also to a refinement of the current ontologies | Descripción: | 15 pages, 6 figures.-- 19604360 [PubMed] | Versión del editor: | htpp://dx.doi.org/10.1186/1752-0509-3-69 | URI: | http://hdl.handle.net/10261/16318 | DOI: | 10.1186/1752-0509-3-69 | ISSN: | 1752-0509 |
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BMC Syst Biol 3-69.pdf | 2,37 MB | Adobe PDF | Visualizar/Abrir |
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