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A single three-dimensional chromatin compartment in amphioxus indicates a stepwise evolution of vertebrate Hox bimodal regulation

AuthorsAcemel, Rafael D.; Tena, Juan J. ; Irastorza-Azcárate, Ibai; Marlétaz, Ferdinand; Gómez-Marín, Carlos ; Calle-Mustienes, Elisa de la ; Diaz, Sergio G.; Holland, Peter W. H.; Devos, Damien P.; Maeso, Ignacio; Escrivá, Hector; Gómez-Skarmeta, José Luis
Issue Date2016
PublisherNature Publishing Group
CitationNature Genetics 48(3): 336-341 (2016)
AbstractThe HoxA and HoxD gene clusters of jawed vertebrates are organized into bipartite three-dimensional chromatin structures that separate long-range regulatory inputs coming from the anterior and posterior Hox-neighboring regions. This architecture is instrumental in allowing vertebrate Hox genes to pattern disparate parts of the body, including limbs. Almost nothing is known about how these three-dimensional topologies originated. Here we perform extensive 4C-seq profiling of the Hox cluster in embryos of amphioxus, an invertebrate chordate. We find that, in contrast to the architecture in vertebrates, the amphioxus Hox cluster is organized into a single chromatin interaction domain that includes long-range contacts mostly from the anterior side, bringing distant cis-regulatory elements into contact with Hox genes. We infer that the vertebrate Hox bipartite regulatory system is an evolutionary novelty generated by combining ancient long-range regulatory contacts from DNA in the anterior Hox neighborhood with new regulatory inputs from the posterior side.
DescriptionAcemel, Rafael D. et al.
Publisher version (URL)https://doi.org/10.1038/ng.3497
Identifiersdoi: 10.1038/ng.3497
e-issn: 1546-1718
issn: 1061-4036
Appears in Collections:(CABD) Artículos
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