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AMPK regulation of cell growth, apoptosis, autophagy, and bioenergetics

AutorVillanueva Paz, Marina; Cotán, David ; Garrido-Maraver, Juan; Oropesa-Ávila, Manuel; Mata, Mario de la ; Delgado Pavón, Ana; Lavera, I. de; Alcocer-Gómez, Elísabet; Álvarez-Córdoba, Mónica; Sánchez-Alcázar, José Antonio
Palabras claveBioenergetics
Apoptosis
Autophagy
Cell growth
AMPK
Fecha de publicación2016
EditorSpringer Nature
CitaciónAMP-activated Protein Kinase: 45-71 (2016)
SerieEXS 107
ResumenIn eukaryotic cells, AMP-activated protein kinase (AMPK) generally promotes catabolic pathways that produce ATP and at the same time inhibits anabolic pathways involved in different processes that consume ATP. As an energy sensor, AMPK is involved in the main cellular functions implicated in cell fate, such as cell growth and autophagy.Recently, AMPK has been connected with apoptosis regulation, although the molecular mechanism by which AMPK induces and/or inhibits cell death is not clear.This chapter reviews the essential role of AMPK in signaling pathways that respond to cellular stress and damage, highlighting the complex and reciprocal regulation between AMPK and their targets and effectors. The therapeutic implications of the role of AMPK in different pathologies such as diabetes, cancer, or mitochondrial dysfunctions are still controversial, and it is necessary to further investigate the molecular mechanisms underlying AMPK activation.
URIhttp://hdl.handle.net/10261/163160
Identificadoresdoi: 10.1007/978-3-319-43589-3_3
isbn: 978-3-319-43587-9
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