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Decreased adult neurogenesis in hibernating Syrian hamster

AuthorsLeón-Espinosa, G.; García, E.; Gómez-Pinedo, Ulises; Hernández, F.; DeFelipe, Javier; Ávila, Jesús CSIC ORCID
Syrian hamster
Issue Date2016
CitationNeuroscience 333: 181- 192 (2016)
AbstractGeneration of new neurons from adult neural stem cells occurs in the dentate gyrus (DG) of the hippocampus and the lateral walls of the lateral ventricles. In this article, we study the neurogenesis that takes place during the hibernation of the Syrian hamster (Mesocricetus auratus). Using a variety of standard neurogenesis markers and 5-bromo-2-deoxyuridine (BrdU) incorporation, we describe a preferential decrease in the proliferation of newborn neurons in the subventricular zone (SVZ) of the hibernating hamsters (torpor) rather than in the hippocampus. Furthermore, we demonstrate that the proliferative capacity is recovered after 3–4 days of torpor when arousal is triggered under natural conditions (i.e., not artificially provoked). In addition, we show that tau3R, a tau isoform with three microtubule-binding domains, is a suitable marker to study neurogenesis both in the SVZ and subgranular zone (SGZ) of the Syrian hamster brain.
Identifiersdoi: 10.1016/j.neuroscience.2016.07.016
issn: 1873-7544
Appears in Collections:(IC) Artículos

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