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The Efflux Pump SmeDEF Contributes to Trimethoprim- Sulfamethoxazole Resistance in Stenotrophomonas maltophilia

AuthorsMaría Blanca Sánchez, José Luis Martínez
Issue Date2015
CitationAntimicrobial Agents and Chemotherapy
AbstractTrimethoprim-sulfamethoxazole (co-trimoxazole) is one of the antimicrobials of choice for the treatment of Stenotrophomonas maltophilia infections. The analysis of mutants either lacking or overexpressing the efflux pump SmeDEF shows that this efflux pump contributes to intrinsic and acquired co-trimoxazole resistance in S. maltophilia. Since SmeDEF can extrude a variety of antibiotics, selection with such antimicrobials, including quinolones, might also select for S. maltophilia co-trimoxazole resistance
Publisher version (URL)http://aac.asm.org/content/59/7/4347.long
Appears in Collections:(CNB) Artículos
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