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Disrupting vegf-vegfr1 interaction: De novo designed linear helical peptides to mimic the VEGF13-25 Fragment

AuthorsBalsera, Beatriz; Bonache de Marcos, María Ángeles CSIC ORCID ; Reille-Seroussi, Marie; Gagey-Eilstein, Nathalie; Vidal, Michel; González-Muñiz, Rosario CSIC ORCID; Pérez de Vega, M. Jesús
Protein–protein interactions
Issue Date2017
PublisherMolecular Diversity Preservation International
CitationMolecules 22 (2017)
AbstractThe interaction between vascular endothelial growth factor (VEGF) and its receptors (VEGFR) has important implications in angiogenesis and cancer, which moved us to search for peptide derivatives able to block this protein-protein interaction. In a previous work we had described a collection of linear 13-mer peptides specially designed to adopt helical conformations (Ac-SSEEXARNXAAXN-NH), as well as the evaluation of seven library components for the inhibition of the interaction of VEGF with its Receptor 1 (VEGFR1). This study led to the discovery of some new, quite potent inhibitors of this protein-protein system. The results we found prompted us to extend the study to other peptides of the library. We describe here the evaluation of a new selection of peptides from the initial library that allow us to identify new VEGF-VEGFR1 inhibitors. Among them, the peptide sequence containing F,W, and I residues at the 5, 9, and 12 positions, show a very significant nanomolar IC50 value, competing with VEGF for its receptor 1, VEGFR1 (Flt-1), which could represent a new tool within the therapeutic arsenal for cancer detection and therapy.
Publisher version (URL)http://dx.doi.org/10.3390/molecules22111846
Identifiersdoi: 10.3390/molecules22111846
issn: 1420-3049
e-issn: 1420-3049
Appears in Collections:(IQM) Artículos
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