English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/162051
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:


Antimicrobial 3D Porous Scaffolds Prepared by Additive Manufacturing and Breath Figures

AuthorsVargas-Alfredo, Nelson; Dorronsoro, Ane; Cortajarena, Aitziber L.; Rodríguez-Hernández, Juan
Issue Date2017
PublisherAmerican Chemical Society
CitationACS Applied Materials and Interfaces 9: 37454-37462 (2017)
AbstractWe describe herein a novel strategy for the fabrication of efficient 3D printed antibacterial scaffolds. For this purpose, both the surface topography as well as the chemical composition of 3D scaffolds fabricated by additive manufacturing were modified. The scaffolds were fabricated by fused deposition modeling (FDM) using high-impact polystyrene (HIPS) filaments. The surface of the objects was then topographically modified providing materials with porous surfaces by means of the Breath Figures approach. The strategy involves the immersion of the scaffold in a polymer solution during a precise period of time. This approach permitted the modification of the pore size varying the immersion time as well as the solution concentration. Moreover, by using polymer blend solutions of polystyrene and polystyrene-b-poly(acrylic acid) (PS-b-PAA) and a quaternized polystyrene-b-poly(dimethylaminoethyl methacrylate) (PS-b-PDMAEMAQ), the scaffolds were simultaneously chemically modified. The surfaces were characterized by scanning electron microscopy and infrared spectroscopy. Finally, the biological response toward bacteria was explored. Porous surfaces prepared using quaternized PDMAEMA as well as those prepared using PAA confer antimicrobial activity to the films, i.e., were able to kill on contact Staphylococcus aureus employed as model bacteria.
Identifiersdoi: 10.1021/acsami.7b11947
issn: 1944-8244
e-issn: 1944-8252
Appears in Collections:(ICTP) Artículos
Files in This Item:
File Description SizeFormat 
accesoRestringido.pdf15,38 kBAdobe PDFThumbnail
Show full item record
Review this work

Related articles:

WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.