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Título: | DNA-Origami-Aided Lithography for Sub-10 Nanometer Pattern Printing |
Autor: | Gállego, Isaac CSIC; Manning, Brendan CSIC; Prades, Joan Daniel; Mir, Mònica; Samitier, Josep; Eritja Casadellà, Ramón CSIC ORCID | Fecha de publicación: | 8-ago-2017 | Editor: | Multidisciplinary Digital Publishing Institute | Citación: | Proceedings 1 (4): 325 (2017) | Resumen: | We report the first DNA-based origami technique that can print addressable patterns on surfaces with sub-10 nm resolution. Specifically, we have used a two-dimensional DNA origami as a template (DNA origami stamp) to transfer DNA with pre-programmed patterns (DNA ink) on gold surfaces. The DNA ink is composed of thiol-modified staple strands incorporated at specific positions of the DNA origami stamp to create patterns upon thiol-gold bond formation on the surface (DNA ink). The DNA pattern formed is composed of unique oligonucleotide sequences, each of which is individually addressable. As a proof-of-concept, we created a linear pattern of oligonucleotide-modified gold nanoparticles complementary to the DNA ink pattern. We have developed an in silico model to identify key elements in the formation of our DNA origami-driven lithography and nanoparticle patterning as well as simulate more complex nanoparticle patterns on surfaces. | Versión del editor: | https://doi.org/10.3390/proceedings1040325 | URI: | http://hdl.handle.net/10261/161426 | DOI: | 10.3390/proceedings1040325 | E-ISSN: | 2504-3900 | Identificadores: | doi: 10.3390/proceedings1040325 |
Aparece en las colecciones: | (IQAC) Artículos |
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